Nodal metastasis characteristics of well-differentiated thyroid cancer in male patients
Main Article Content
Abstract
This study aims to assess the nodal metastasis characteristics of differentiated thyroid cancer in male patients at Hanoi Medical University Hospital. We conducted a prospective cohort study of 102 male patients with well-differentiated thyroid carcinoma who were treated by surgery at Hanoi Medical University Hospital from July 2018 to August 2020. The mean age was 40.9 ± 13.0. Most patients (79.4%) had unilateral tumor, with diameter ≤ 1cm (65.7%). About two third (66.6%) of the tumors were classified as TIRADS 4 according to ultrasound, and FNA indicated malignant result in 74.5% cases. Total thyroidectomy was performed on 67.6% patients. The overall rate of nodal metastasis was 59.8%. Central neck compartment nodal metastasis was detected in 56.1% of the cases, while 33.3% patients had positive nodes in both central and lateral neck. The occult nodal metastasis rate was 47.1%. Nodal metastasis was significantly associated with the following factors: tumor size > 1 cm, bilateral tumor, and extrathyroidal extension (p < 0.05).
Article Details
Keywords
differentiated thyroid cancer, male, lymph node metastasis
References
2. Nguyễn Bá Đức (2009). Ung Thư Tuyến Giáp, Nhà Xuất Bản Y Học, 15 - 19.
3. Zeng Q, Chen GG, Vlantis AC, van Hasselt CA. Oestrogen mediates the growth of human thyroid carcinoma cells via an oestrogen receptor - ERK pathway. Cell Prolif. 2007;40(6):921-935. doi:10.1111/j.1365-2184.2007.00471.x.
4. Ricarte-Filho J, Ganly I, Rivera M, et al. Papillary thyroid carcinomas with cervical lymph node metastases can be stratified into clinically relevant prognostic categories using oncogenic BRAF, the number of nodal metastases, and extra-nodal extension. Thyroid. 2012;22(6):575-584. doi:10.1089/thy.2011.0431.
5. Micheli A, Ciampichini R, Oberaigner W, et al. The advantage of women in cancer survival: an analysis of EUROCARE-4 data. Eur J Cancer. 2009;45(6):1017-1027. doi:10.1016/j.ejca.2008.11.008.
6. Hsieh S-H, Chen S-T, Hsueh C, Chao T-C, Lin J-D. Gender-Specific Variation in the Prognosis of Papillary Thyroid Cancer TNM Stages II to IV. International Journal of Endocrinology. doi:10.1155/2012/379097.
7. Yan H-X, Pang P, Wang F-L, et al. Dynamic profile of differentiated thyroid cancer in male and female patients with thyroidectomy during 2000-2013 in China: a retrospective study. Sci Rep. 2017;7(1):15832. doi:10.1038/s41598-017-14963-z.
8. Liu C, Chen T, Zeng W, et al. Reevaluating the prognostic significance of male gender for papillary thyroid carcinoma and microcarcinoma: a SEER database analysis. Sci Rep. 2017;7. doi:10.1038/s41598-017-11788-8.
9. Bertakis KD. The influence of gender on the doctor-patient interaction. Patient Educ Couns. 2009;76(3):356-360. doi:10.1016/j.pec.2009.07.022.
10. Nguyễn Tiến Lãng. Đánh giá kết quả phẫu thuật cắt bỏ tuyến giáp phối hợp với I131 điều trị ung thư tuyến giáp thể biệt hóa. Published online 2008.
11. Nguyễn Xuân Hậu. Đặc điểm lâm sàng, cận lâm sàng và tình trạng di căn hạch của ung thư tuyến giáp tại Bệnh viện Đại học Y Hà Nội. Tạp chí Y học. 2017;451(2):138-142.
12. Machens A, Hauptmann S, Dralle H. Disparities between male and female patients with thyroid cancers: sex difference or gender divide? Clin Endocrinol (Oxf). 2006;65(4):500-505. doi:10.1111/j.1365 - 2265.2006.02623.x.
13. Nie X, Tan Z, Ge M. Skip metastasis in papillary thyroid carcinoma is difficult to predict in clinical practice. BMC Cancer. 2017;17. doi:10.1186/s12885-017-3698-2.
14. Quang LV, Hieu NV, Hau NX, Hung NV. Role of Sentinel Lymph Node Biopsy in Papillary Thyroid Carcinoma in Vietnam. uhod. 30(2):230-237.
15. Nguyễn Thị Thu Nhung. Đánh giá tình trạng di căn hạch tiềm ẩn trong ung thư biểu mô tuyến giáp giai đoạn sớm tại bệnh viện Đại học Y Hà Nội. Luận văn thạc sĩ y học. 2019. Trường Đại học Y Hà Nội.
16. Liu L-S, Liang J, Li J-H, et al. The incidence and risk factors for central lymph node metastasis in cN0 papillary thyroid microcarcinoma: a meta-analysis. Eur Arch Otorhinolaryngol. 2017;274(3):1327-1338. doi:10.1007/s00405-016-4302-0.
17. Qu N, Zhang L, Ji Q-H, et al. Risk Factors for Central Compartment Lymph Node Metastasis in Papillary Thyroid Microcarcinoma: A Meta-Analysis. World J Surg. 2015;39(10):2459-2470. doi:10.1007/s00268-015-3108-3.