16. Primary diffuse large b-cell lymphoma presenting as a chest wall mass: A case report
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Abstract
Chest wall lymphoma is a rare entity and often confused with the more common sarcoma. We report a case of diffuse large B-cell non-Hodgkin lymphoma patient presented with a sole chest wall mass. Chest computed tomography revealed an abnormal mass with well-defined borders below the pectoralis major muscle with contrast enhancement. The excisional biopsy revealed diffuse large B-cell non-Hodgkin lymphoma, confirmed by immunohistochemistry. The patient was then treated with six cycles of R-CHOP and achieved complete response. She is currently free from malignancy for 12 months after treatment. This paper illustrates the rarity of this entity, the need for distinguishing it from sarcoma, and briefly reviews its current management.
Article Details
Keywords
DLBCL, soft tissue lymphoma, chest wall lymphoma
References
2. Travis WD, Banks PM, Reiman HM. Primary extranodal soft tissue lymphoma of the extremities. Am J Surg Pathol. 1987; 11(5): 359-366. doi:10.1097/00000478-198705000-00004.
3. Bellini A, Ferrigno P, Comacchio GM, et al. Primary malignant chest wall tumors: surgical management and factors predicting survival. Curr Chall Thorac Surg. 2019; 1(0). doi: 10.21037/ccts.2019.11.08.
4. Derenzini E, Casadei B, Pellegrini C, Argnani L, Pileri S, Zinzani PL. Non-Hodgkin Lymphomas Presenting as Soft Tissue Masses: A Single Center Experience and Meta-Analysis of the Published Series. Clin Lymphoma Myeloma Leuk. 2013; 13(3): 258-265. doi:10.1016/j.clml.2012.10.003.
5. Lanham GR, Weiss SW, Enzinger FM. Malignant lymphoma. A study of 75 cases presenting in soft tissue. Am J Surg Pathol. 1989;13(1):1-10.
6. Salamao DR, Nascimento AG, Lloyd RV, Chen MG, Habermann TM, Strickler JG. Lymphoma in soft tissue: a clinicopathologic study of 19 cases. Hum Pathol. 1996; 27(3): 253-257. doi:10.1016/s0046-8177(96)90065-9
7. Aozasa K, Takakuwa T, Nakatsuka S ichi. Pyothorax-associated lymphoma: a lymphoma developing in chronic inflammation. Adv Anat Pathol. 2005; 12(6): 324-331. doi:10.1097/01.pap.0000194627.50878.02.
8. Nakatsuka SI, Yao M, Hoshida Y, Yamamoto S, Iuchi K, Aozasa K. Pyothorax-associated lymphoma: a review of 106 cases. J Clin Oncol Off J Am Soc Clin Oncol. 2002;20(20):4255-4260. doi:10.1200/JCO.2002.09.021.
9. Zelenetz, Andrew D., et al. NCCN Guidelines® Insights: B-Cell Lymphomas, Version 5.2021: Featured Updates to the NCCN Guidelines. Journal of the National Comprehensive Cancer Network. 2021; 19.11(2): 1218-1230.
10. Sehn, Laurie H., et al. No added benefit of eight versus six cycles of CHOP when combined with rituximab in previously untreated diffuse large B-cell lymphoma patients: results from the international phase III GOYA study. Blood. 2018; 132:783. doi: 10.1182/blood-2018-99-116845
11. Aviles, Agustin, et al. Role of radiotherapy in diffuse large B-cell lymphoma in advanced stages on complete response after administration of cyclophosphamide, doxorubicin, vincristine, prednisone, and rituximab. Precision Radiation Oncology. 2019; 3.3:100-104. doi: 10.1002/pro6.1071
12. Hsu PK, Hsu HS, Li AFY, et al. Non-Hodgkin’s Lymphoma Presenting as a Large Chest Wall Mass. Ann Thorac Surg. 2006; 81(4): 1214-1218. doi:10.1016/j.athoracsur.2005.11.044
13. Qiu X, Liu Y, Qiao Y, et al. Primary diffuse large B-cell lymphoma of the chest wall: a case report. World J Surg Oncol. 2014; 12(1): 104. doi:10.1186/1477-7819-12-104