Surgical outcome of well-differentiated thyroid cancer in male patients
Main Article Content
Abstract
Thyroid cancer in men has distinguished features compared to women, such as larger tumors and a higher rate of nodal metatstasis, which afftects surgical plan and outcome. This is a prospective study on 102 males with well-differentiated thyroid carcinoma treated by surgery at Hanoi Medical University Hospital from July 2018 to August 2020. The proportions of total thyroidectomy and lymph node dissection were 68% and 85.3% respectively. Recurrent laryngeal nerve injury and hypocalcemia were the two most common complications, accounting for 11.8% and 15.7% after 72h respectively, in which patients with total thyroidectomy had higher rates. Complications were also more common among patients with lymph node dissection, but the difference was not statistically significant. Prophylactic lymph node dissection should be considered in males with well-differentiated thyroid carcinoma.
Article Details
Keywords
differentiated thyroid cancer, male, surgical outcome
References
2. Schonfeld SJ, Neta G, Sturgis EM, et al. Common Genetic Variants in Sex Hormone Pathway Genes and Papillary Thyroid Cancer Risk. Thyroid. 2012;22(2):151-156. doi:10.1089/thy.2011.0309.
3. Zeng Q, Chen GG, Vlantis AC, van Hasselt CA. Oestrogen mediates the growth of human thyroid carcinoma cells via an oestrogen receptor-ERK pathway. Cell Prolif. 2007;40(6):921-935. doi:10.1111/j.1365-2184.2007.00471.x.
4. Mitchell I, Livingston EH, Chang AY, et al. Trends in thyroid cancer demographics and surgical therapy in the United States. Surgery. 2007;142(6):823-828; discussion 828.e1. doi:10.1016/j.surg.2007.09.011.
5. Haddad RI, Nasr C, Bischoff L, et al. NCCN Guidelines Insights: Thyroid Carcinoma, Version 2.2018. Journal of the National Comprehensive Cancer Network. 2018;16(12):1429-1440. doi:10.6004/jnccn.2018.0089.
6. Hoàng Huy Hùng. Đánh giá di căn hạch của ung thư biểu mô tuyến giáp. Luận văn Bác sỹ nội trú. Trường Đại học Y Hà Nội; 2016.
7. Rago T, Fiore E, Scutari M, et al. Male sex, single nodularity, and young age are associated with the risk of finding a papillary thyroid cancer on fine-needle aspiration cytology in a large series of patients with nodular thyroid disease. Eur J Endocrinol. 2010;162(4):763-770. doi:10.1530/EJE-09-0895.
8. Berri RN, Lloyd LR. Defining the role of fine-needle aspiration of thyroid nodules in male patients: is it necessary? Am J Surg. 2008;195(3):396-398; discussion 398-400. doi:10.1016/j.amjsurg.2007.12.007.
9. Schiro AJ, Pinchot SN, Chen H, Sippel RS. Clinical Efficacy of Fine-Needle Aspiration Biopsy of Thyroid Nodules in Males. J Surg Res. 2010;159(2):645-650. doi:10.1016/j.jss.2009.08.013.
10. Mai Thế Vương. Nhận xét đặc điểm lâm sàng, cận lâm sàng và kết quả phẫu thuật của bệnh nhân vi ung thư tuyến giáp thể nhú tại Bệnh viện K. Luận văn thạc sĩ y học. Trường Đại học Y Hà Nội; 2019.
11. Sands NB, Payne RJ, Côté V, Hier MP, Black MJ, Tamilia M. Female gender as a risk factor for transient post-thyroidectomy hypocalcemia. Otolaryngol Head Neck Surg. 2011;145(4):561-564. doi:10.1177/0194599811414511.
12. Cho JN, Park WS, Min SY. Predictors and risk factors of hypoparathyroidism after total thyroidectomy. International Journal of Surgery. 2016;34:47-52. doi:10.1016/j.ijsu.2016.08.019.
13. Del Rio P, Rossini M, Montana CM, et al. Postoperative hypocalcemia: analysis of factors influencing early hypocalcemia development following thyroid surgery. BMC Surgery. 2019;18(1):25. doi:10.1186/s12893-019-0483-y.
14. Joliat G-R, Guarnero V, Demartines N, Schweizer V, Matter M. Recurrent laryngeal nerve injury after thyroid and parathyroid surgery: Incidence and postoperative evolution assessment. Medicine (Baltimore). 2017;96(17):e6674. doi:10.1097/MD.0000000000006674.
15. Trần Văn Thông. Đánh giá kết quả sớm phẫu thuật ung thư tuyến giáp tại bệnh viện Đại học Y Hà Nội. Luận văn thạc sĩ y học. Trường Đại học Y Hà Nội; 2014.
16. AlSaiegh AM. Correlation Between Types of Thyroid Surgery, Goitre Pathology, and Recurrent Laryngeal Nerve Injury-Retrospective Cohort Study. Journal of Surgery and Research. 2020;3(2):86-95.
17. Chadwick DR. Hypocalcaemia and permanent hypoparathyroidism after total/bilateral thyroidectomy in the BAETS Registry. Gland Surg. 2017;6(Suppl 1):S69-S74. doi:10.21037/gs.2017.09.14.
18. Giordano D, Valcavi R, Thompson GB, et al. Complications of central neck dissection in patients with papillary thyroid carcinoma: results of a study on 1087 patients and review of the literature. Thyroid. 2012;22(9):911-917. doi:10.1089/thy.2012.0011.