Article Sidebar

PDF (Tiếng Việt)
Published: 2022-06-11
Abstract Views: 212
Views PDF (Tiếng Việt): 136
DOI: https://doi.org/10.52852/tcncyh.v154i6.870
Issue
Vol. 154 No. 6 (2022): Tập 154 số 6 E10
Section
Các bài báo
How to Cite
Anh, P. T. V., Hang, V. V. ., Duongg, D. T., Quang, T. V., Quan, L., Van, N. H., Hue, N. T. V., Sy, D. T., Tri, N. P., Anh, N. T. V., Hao, D. T. P., Minh, N. T., & Linh , D. D. (2022). 19. Androgenic properties of “Dong Trung Ha Thao Sapa” hard capsules on experimental animals. Journal of Medical Research, 154(6), 153-160. https://doi.org/10.52852/tcncyh.v154i6.870

19. Androgenic properties of “Dong Trung Ha Thao Sapa” hard capsules on experimental animals

Pham Thi Van Anh, Vu Viet Hang, Dau Thuy Duong, Trinh Vinh Quang, Le Quan, Nguyen Huy Van, Nguyen Thi Vinh Hue, Do Tien Sy, Nguyen Phu Tri, Nguyen Thi Van Anh, Dang Thi Phuongg Hao, Nguyen Thu Minh, Do Dieu Linh

Main Article Content

Abstract

“Dong trung ha thao Sapa” (DTHT) hard capsules prepared from Cordyceps militaris powder are intended to treat male hypogonadism. The aim of the current study was to evaluate the androgenic properties of this product on experimental animals. Weanling male rats and castrated peripubertal male rats were used for the study. Weanling male rats were divided into 5 groups: group I (saline-treated); group II (testosterone undecanoate-treated); group III (low dose DTHT capsules); and group IV (high dose DTHT capsules). Castrated peripubertal male rats were also divided into 5 groups: group I without castration (saline-treated); groups II to V were surgically castrated, group II (saline-treated); group III (testosterone undecanoate-treated), group IV (low dose DTHT capsules) and group V (high dose DTHT capsules). The potential effect was evaluated on five androgen-dependent tissue weight (seminal vesicles, ventral prostate, Cowper’s gland, glans penis, levator ani-bulbocavernosus - LABC muscle and the serum testosterone level in castrated rats. Five tissue weights and testes, epididymis weights were examined in weanling rats. A positive androgen agonist result should be a statistically significant increase (p ≤ 0.05) in any two or more of the five targets’ androgen-dependent tissue. The results suggest that capsules show androgenic properties in castrated male rats by increasing weight of 3 tissues (seminal vesicles, ventral prostate, LABC muscle). DTHT hard capsules appear to be an effective therapeutic drug for treating hypogonadism.

Article Details

Keywords

Cordyceps militaris, hard capsules, hypogonadism, weanling rats, castration, testosterone undecanoate

References

1. Salonia A, Rastrelli G, Hackett G, et al. Paediatric and adult-onset male hypogonadism. Nat Rev Dis Primer. 2019;5(1).
2. Wu FCW, Tajar A, Pye SR, et al. Hypothalamic - pituitary - testicular axis disruptions in older men are differentially linked to age and modifiable risk factors: the European Male Aging Study. J Clin Endocrinol Metab. 2008; 93(7): 2737-2745.
3. A. Salonia, et al. EAU Guideline on male hypogonadism. 2020.
4. Chang Y, Jeng KC, Huang KF, et al. Effect of Cordyceps militaris supplementation on sperm production, sperm motility and hormones in Sprague-Dawley rats. Am J Chin Med. 2008; 36(5): 849-859.
5. Won SY, Park EH. Anti-inflammatory and related pharmacological activities of cultured mycelia and fruiting bodies of Cordyceps militaris. J Ethnopharmacol. 2005; 96(3): 555-561.
6. OECD 441. “OECD guidelines for the testing of chemicals: Hershberger Bioassay in Rats: A Short-term Screening Assay for (Anti) Androgenic Properties”. 2006.
7. OECD 115. “OECD guidlines for the testing of chemical: Hershberger Bioassay in Rats: A Short – term Screening Assay for (Anti) Androgenic Properties.” 2009.
8. Kashyap, D., Tuli, H. S., and Sharma, A. K. Cordyceps: A Natural Himalayan Viagra with Promising Aphrodisiac Potential. Austin Androl. 2016.
9. Sohn SH, Lee SC, Hwang SY, et al. Effect of long-term administration of cordycepin from Cordyceps militaris on testicular function in middle-aged rats. Planta Med. 2012; 78(15): 1620-1625.
10. Hong IP. Effect of Cordyceps militaris on Testosterone Production in Sprague-Dawley Rats. Korean Soc Sericultural Sci. 2011.
11. Kusama K, Miyagawa M, Ota K, et al. Cordyceps militaris Fruit Body Extract Decreases Testosterone Catabolism and Testosterone-Stimulated Prostate Hypertrophy. Nutrients. 2020; 13(1): 50.
12. Liu Y, Wang J, Wang W, Zhang H, Zhang X, Han C. The Chemical Constituents and Pharmacological Actions of Cordyceps sinensis. Evid-Based Complement Altern Med ECAM. 2015; 2015: 575063.
13. Wang J, Chen C, Jiang Z, Wang M, Jiang H, Zhang X. Protective effect of Cordyceps militaris extract against bisphenol A induced reproductive damage. Syst Biol Reprod Med. 2016;62(4):249-257.