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Published: 2022-06-11
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DOI: https://doi.org/10.52852/tcncyh.v154i6.873
Issue
Vol. 154 No. 6 (2022): Tập 154 số 6 E10
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Các bài báo
How to Cite
Huong, T. T. ., Hoc, T. H., Cuong, N. C., & Son, T. Q. (2022). 20. Clinical features, microbiology, and vancomycin regimens in sepsis patients: A retrospective study conducted at a single infectious diseases center. Journal of Medical Research, 154(6), 161-168. https://doi.org/10.52852/tcncyh.v154i6.873

20. Clinical features, microbiology, and vancomycin regimens in sepsis patients: A retrospective study conducted at a single infectious diseases center

Tran Thu Huong, Tran Hieu Hoc, Ngo Chi Cuong, Tran Que Son

Main Article Content

Abstract

Despite increasing antibiotic resistance, vancomycin remains the first choice to treat severe infections due to drug-resistant gram-positive bacteria. This study aimed to summarise the clinical, microbiological, and vancomycin treatment outcomes in bacteremia patients. From July to December 2019, a retrospective cohort analysis was conducted on patients with bacteremia treated with vancomycin at a tertiary hospital in Hanoi, Vietnam. Patients without vancomycin concentrations were excluded from the study. Patients had a median age of 54 years (IQR, 41.8 - 63.3), with a male/female ratio of 1.86. Renal complication was markedly different; Clcr < 60, 60 - 130, and > 130 mL/min was 29%, 60%, and 11%, respectively. The median Charlson score was 3.0 (2-4.3), the qSOFA score was 1 (1-2), and the NEWS score was 76%, with a median of 6 (5-8). Twenty-one cases had positive blood culture where85.7% were gram-positive. 93% of patients with sepsis were treated with vancomycin as the first antimicrobial, of which 72% used vancomycin in combination with other antibiotics. Renal complications occurred in 12% of all patients, with grades R, I, and F accounting for 4%, 5%, and 3%, respectively. The median duration of treatment was 12 days (IQR, 7-17), with a success rate of 82 % and a failure rate of 18%, respectively.


Conclusions: In most patients with bacteremia, microbiological tests reveal no detectable bacteria. When sepsis is suspected, a vancomycin regimen should be initiated.

Article Details

Keywords

Vancomycin, Treatment Outcome, Bacteremia, Anti-Bacterial Agents, AUC/MIC

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