11. Evaluation of first-line Afatinib treatment in advanced EGFR-mutant non-small cell lung cancer patients
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Abstract
This is a retrospective, descriptive study with longitudinal follow-up aimed at evaluating the efficacy and tolerability of first-line afatinib treatment in stage IV non-small cell lung cancer (NSCLC) with EGFR mutations at Hanoi Medical University Hospital. Treatments are from January 2018 to June 2021. Of 34 patients enrolled in the study, the rate of Del19 and L585R mutations was 44.1% and 20.6%, respectively; the remaining cases were rare mutations or compound mutations. After 12 weeks, 76.5% responded to treatment, 20.6% had stable condition, and only 2.9% had progression. The median progression-free survival (PFS) was 12.0 ± 3.1 months (5.9 - 18.0 months). The most common toxicities were skin rash (35.3%), paronychia (35.3%), and diarrhea (32.4%). There was no patient who reported grade 4 toxicity or discontinued treatment due to afatinib's toxicity.
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Keywords
advanced non-small cell lung cancer, EGFR mutation, afatinib
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