Article Sidebar

PDF (Tiếng Việt)
Published: 2022-10-06
Abstract Views: 208
Views PDF (Tiếng Việt): 290
DOI: https://doi.org/10.52852/tcncyh.v157i9.913
Issue
Vol. 157 No. 9 (2022)
Section
Các bài báo
How to Cite
Hằng, V. V. ., & Vân Anh, P. T. . (2022). 17. Anti-inflammatory and analgesic activities of Tecan capsules in experimental animal models. Journal of Medical Research, 157(9), 140-146. https://doi.org/10.52852/tcncyh.v157i9.913

17. Anti-inflammatory and analgesic activities of Tecan capsules in experimental animal models

Vu Viet Hang, Pham Thi Van Anh

Main Article Content

Abstract

 This study was done to investigate the analgesic and acute anti-inflammatory effects of Tecan capsules. The capsules were evaluated for analgesic activity using hot plate and acetic acid-induced writhing methods in Swiss mice. The pre-treatment with Tecan (1.44 capsules/kg and 4.32 capsules/kg doses) was able to inhibit the number of abdominal writhes in the animals, but this treatment did not affect the behavior of animals in the hot plate test. For the acute anti-inflammatory activity, carrageenan-induced peritonitis model was used in Wistar rats. A reduction in inflammatory exudate volume and cell migration was seen with all test doses (0.72 and 2.16 capsules/kg) evaluated. The results of this study suggested that Tecan capsules have acute anti-inflammatory and peripheral antinociceptive properties.

Article Details

Keywords

Tecan capsules, anti-inflammatory, analgesic

References

1. Hanoch Kumar K, Elavarasi P. Definition of pain and classification of pain disorders. Journal of Advanced Clinical & Research Insights. 2015;3:87-90.
2. Medzhitov R. Origin and physiological roles of inflammation. Nature. 2016;454:428-435.
3. Đỗ Tất Lợi. Xạ can. Những cây thuốc và vị thuốc Việt Nam. Nhà xuất bản Y học. 2004;653-654.
4. Woźniak D, Matkowski A. Belamcandae chinensis rhizome - A review of phytochemistry and bioactivity. Fitoterapia. 2015;107:1-14.
5. Gerhard Vogel H. Chapter H: Analgesic, anti-inflammatory, anti-pyretic activity. Drug discovery and evaluation Pharmacological assays. Springer. 2016;669-774.
6. Cheng J, Ma T, Liu W, et al. In in vivo evaluation of the anti-inflammatory and analgesic activities of compound Muniziqi granule in experimental animal models. BMC complementary and alternative medicine. 2016;16,20. doi: 10.1186/s12906-016-0999-y.
7. Kim KS, Rhee HI, Park EK, et al. Anti-inflammatory effects of Radix Gentianae Macrophyllae (Qinjiao), Rhizoma Coptidis (Huanglian) and Citri Unshiu Pericarpium (Wenzhou migan) in animal models. Chinese medicine. 2008;3,10. https://doi.org/10.1186/ 1749-8546-3-10.
8. Matta CBB, Cavalcante-Silva LHA, Araújo-Júnior JX, et al. Antinociceptive and Anti-inflammatory Effects of Caulerpa kempfii (Caulerpaceae). Revista Virtual de Química. 2015; 7:730-743.
9. Panda BB, Gaur Kalpesh, Kori ML, et al. Anti-inflammatory and analgesic activity of jatropha gossypifolia in experimental animal models. Global Journal of Pharmacology. 2009; 3(1):01-05.
10. Ezaki S. Pharmacological studies of tectoridin and tectorigenin. Nihon Yakurigaku Zasshi. 1968;64(2):186-198.
11. Xin RH, Zheng JF, Chen LP, et al. Belamcanda chinensis (L.) DC: Ethnopharmacology, phytochemistry and pharmacology of an important Traditional Chinese Medicine. African Journal of Traditional, Complementary and Alternative Medicines. 2015;2(6):39-70.
12. Ahn KS, Noh EJ, Cha KH, et al. Inhibitory effects of Irigenin from the rhizomes of Belamcanda chinensis on nitric oxide and prostaglandin E(2) production in murine macrophage RAW 264.7 cells. Life Sci. 2006;78(20):2336-2342.
13. Pan CH, Kim ES, Jung SH, et al. Tectorigenin inhibits IFN-gamma/LPS-induced inflammatory responses in murine macrophage RAW 264.7 cells. Arch Pharm Res. 2008; 31(11):1447-1456.