7. Đặc điểm lâm sàng, cận lâm sàng viêm não kháng thụ thể n-methyl-d-aspartate (nmda) sau viêm não herpes simplex ở trẻ em

Abstract

This is a  report of clinical and subclinical characteristics of 11 pediatricpatients with relapsing symptoms post–herpes simplex encephalitis. This is a Descriptive case study –of patients diagnosed between November 2019 and December 2021. All patients had negative PCR for HSV and the cerebrospinal fluid was positive for anti-NMDA receptor antibodies. Mean time from herpes simplex encephalitis until probable autoimmune encephalitis was 22.9 ± 7.4 days. The most common symptoms were choreoathetosis (diskinesis) (81.8%), impaired consciousness and relapsing fever (63.6%). Cerebrospinal fluid showed increased white blood cell count and total protein concentration. EEG showed focal or diffuse slow waves and almost all MRI showed no new necrosis. Anti-NMDA receptor encephalitis post HSV encephalitis can be observed in  children. Clinicians should be considered  testing for anti-NMDA receptor antibodies in cerebrospinal fluid if a patient has relapsing or new neurologic symptoms.