20. Effects of a mixture extract of camellia chrysantha and gynostemma pentaphyllum on weight loss and lowering lipid blood levels in obese mice models
Main Article Content
Abstract
The purpose of this study was to evaluate the effects of a mixture extract of C.chrysantha and G.pentaphyllum on weight loss and lowering lipid blood levels in obese Swiss mice. Swiss mice were randomly allocated into 5 groups with 8 animals in each group. Group 1: non-obese mice. With the remaining 4 groups, the mice were induced to become obese for 8 weeks. mice were fed with distilled water ( group 2) mixture extract at a dose of 12g/kg/day ( group 3), , 24g/kg/day ( group 4) and atorvastatin at a dose of 15mg/kg/day ( group 5). The feeding time period was 14 days. Mice in each group was assessed for weight weekly and the levels of Total Cholesterol (CT), HDL-Cholesterol (HDL-C), LDL-Cholesterol (LDL-C) and Triglyceride (TC) was recorded at initial time (after obesity was induced for 8 weeks) and 1 hour after taking the extracted mixtures on the last day. The results showed that the mixture extract of C.chrysantha and G.pentaphyllum at doses of 12 g/kg/day and 24 g/kg/day, atorvastatin at a dose of 15 mg/kg/day (group 3,4,5) induced weight loss and decreased TC, CT, LDL-C levels compared with group 2 (p < 0.05) and the difference was not statistically significant between groups 3,4,5 (p > 0.05).
Article Details
Keywords
Camellia chrysantha Ninh, Gynostemma pentaphyllum (Thunb.) Makino, Obesity, Dyslipidemia, Swiss mice
References
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