4. Subchronic toxicity study of efcovida powder in experimental animals

Trinh Dinh Nang, Nguyen Minh Hai, Tran Thi Thu Huong, Vo Quang Tuyen, Do Linh Quyen, Pham Thi Van Anh, Nguyen Thi Thanh Loan

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Abstract

The purpose of this study was to evaluate the subchronic toxicity of Efcovida powder through oral administration in experimental animals. The subchronic toxicity was studied in Wistar rats with oral doses of 90 mg/kg/day and 270 mg/kg/day in 90 consecutive days based on guidance of the World Health Organization and Organisation for Economic Co-operation and Development. Our result showed that Efcovida powder had no deleterious effect on hematological parameters, hepato-renal functions, macroscopic and microscopic images of livers and kidneys of rats. In conclusion, Efcovida powder did not produce the subchronic toxicity in experimental animals.

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References

1. Kroto H., Heath J. R., O’Brien S. C., et al. C60: buckminsterfullerene. Nature. 1985; 318(6042): 162–163.
2. P Poulomi Bhakta, Bhavna Barthunia. Fullerene and its Applications: A Review. Journal of Indian Academy of Oral Medicine & Radiology. 2020; 32(2): 159-163.
3. Nemi Malhotra, Gilbert Audira, Agnes L. Castillo et al. An Update Report on the Biosafety and Potential Toxicity of Fullerene-Based Nanomaterials toward Aquatic Animal. Oxidative Medicine and Cellular Longevity. 2021; 7995223: 1-14.
4. World Health Organization. Global report on traditional and complementary medicine. 2019.
5. OECD. Guidelines for the testing of chemicals repeated dose oral toxicity study in rodents. Environmental Health and Safety Monograph Series on Testing and Assesment No 407. 2008.
6. World Health Organization. Working group on the safety and efficacy of herbal medicine. Report of regional office for the western pacific of the World Health Organization. 2000.
7. De Jong WH, Carraway JW, Geertsma RE. In vivo and in vitro testing for the biological safety evaluation of biomaterials and medical devices. Biocompatibility and Performance of Medical Devices. 2012; 120-158.
8. Saganuwan S.A. Toxicity studies of drugs and chemicals in animals: an overview. Bulgarian Journal of Veterinary Medicine. 2017; 4(20): 291-318.
9. Olson H, Betton G, Robinson D, et al. Concordance of the toxicity of pharmaceuticals in humans and in animals. Regulatory Toxicology and Pharmacology. 2000; 32(1): 56- 67.
10. Zhao GX, Song L. Study on acute toxicity and 30 days feeding test of Cinnamomi ramulus. Hubei Journal of Traditional Chinese Medicine.2014; 36: 23–24.
11. Chanakan Jantawong, Aroonsri Priprem, Kitti Intuyod et al. Curcumin-loaded nanocomplexes: Acute and chronic toxicity studies in mice and hamsters. Toxicology Reports. 2021; 8: 1346–1357.
12. Hyun-Yong Kim, Guanglei Zuo, Soo Kyeong Lee et al. Acute and subchronic toxicity study of nonpolar extract of licorice roots in mice Food Science and Nutrition. 2020; 8: 2242–2250.
13. Dong-Gu Kim, Jeonghoon Lee, Wonnam Kim et al. Assessment of General Toxicity of the Glycyrrhiza New Variety Extract in Rats. Plants. 2021; 10: 1126-114.