3. Characteristics of autologous bone marrow stem cell unit derived from bone marrow sample for supportive treatment of biliary atresia at vietnam national children’s hospital
Main Article Content
Abstract
Biliary atresia is one of the most common causes of persistent jaundice in the neonatal period. Treatment of this condition still remains challenging with poor prognosis. This study was carrried out to describe characteristics of autologous bone marrow stem cell unit derived from bone marrow samples for supportive treatment of biliary atresia. We conducted a case series of 30 patients diagnosed with biliary atresia and undergone Kasai surgery combined with stem cell therapy at Vietnam National Children’s Hospital. The results showed that in bone marrow stem cell units, the average number of total nucleated and mononuclear cells was 0.88 ± 0.28 × 109 cells and 0.51 ± 0.16 ×109 cells, respectively. The average number of hematopoietic stem cells and mesenchymal stem cells was 40.32 ± 17.63 × 106 cells and 118.2 ± 17.71 × 103 cells. The dose of mononuclear cells, hematopoietic stem cells and mesenchymal stem cells injected to patients was 0.1× 109, 7.38 × 106 and 3.13 × 103 cells/kg body weight, respectively. All bone marrow stem cell units have the standard criteria for supportive treatment of biliary atresia patients.
Article Details
Keywords
Biliary atresia, Autologous bone marrow cell therapy, Vietnam National Children’s Hospital
References
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