Thanh bên bài viết

PDF
Đã xuất bản: 2022-12-28
Số lượt xem tóm tắt: 95
Số lượt xem PDF: 162
DOI: https://doi.org/10.52852/tcncyh.v161i12E11.1084
Số xuất bản
Tập 161 Số 12E11 (2022): Tập 161 Số 12 E11
Chuyên mục
Các bài báo
Cách trích dẫn
Quyen, D. L., Trung, D. V., Anh, P. T. V. ., & Loan, N. T. T. (2022). 9. Anxiolytic effect of the herbal remedy “Ky cuc dia hoang thang gia vi” in experimental animals. Tạp Chí Nghiên cứu Y học, 161(12E11), 69-77. https://doi.org/10.52852/tcncyh.v161i12E11.1084

9. Anxiolytic effect of the herbal remedy “Ky cuc dia hoang thang gia vi” in experimental animals

Do Linh Quyen, Doan Van Trung, Pham Thi Van Anh, Nguyen Thi Thanh Loan

Nội dung chính của bài viết

Tóm tắt

The present study evaluated the anxiolytic effect of the herbal remedy “Ky cuc dia hoang thang gia vi” in experimental animals. Swiss mice were treated with “Ky cuc dia hoang thang gia vi” remedy at 31.2 and 62.4 g/kg per day for seven consecutive days. The anxiolytic effect of “Ky cuc dia hoang thang gia vi” was assessed in mice using elevated plus maze, spontaneous locomotor activity, rotarod performance and grip strength tests. The results showed that “Ky cuc dia hoang thang gia vi” remedy increased the frequency and time in the open arms and decreased the index of open arm avoidance. Moreover, “Ky cuc dia hoang thang gia vi” remedy inhibited spontaneous locomotion, shortened the stay time on the rotating cylinder in rotarod performance test, and reduced the force in the grip strength test. No statistically significant difference in the anxiolytic effect was found between two doses after three hours of the last administration. Our findings demonstrated that “Ky cuc dia hoang thang gia vi” remedy exerted anxiolytic effect. The rationale for the ethnomedicinal use of “Ky cuc dia hoang thang gia vi” remedy for the management of anxiety was confirmed scientifically in this study.

Chi tiết bài viết

Từ khóa

Ky cuc dia hoang thang gia vi, anxiolytic, experimental animals

Tài liệu tham khảo

1. Shiv Gautam, Akhilesh Jain, Manaswi Gautam et al. Clinical practice guidelines for management of generalised anxiety disorder and panic disorder. Indian Journal of Psychiatry. 2017; 59(Suppl 1): S67-S73.
2. Borwin Bandelow, Sophie Michaelis Epidemiology of anxiety disorders in the 21st century. Dialogues in Clinical Neuroscience. 2015; 17(3): 327-335.
3. Kroenke K, Spitzer RL, Williams JB, Monahan PO et al. Anxiety disorders in primary care: prevalence, impairment, comorbidity, and detection. Annals of Internal Medicine. 2007; 146(5): 317-325.
4. World Health Organization. Guidelines for Assessing Quality of Herbal Medicines With Reference to Contaminants and Residues. World Health Organization, Geneva. 2007.
5. Nguyen Van Tam, Nguyen Tran Giang Huong, Pham Thi Van Anh et al. Evaluate sedative and anxiolytic effects of the “Duong tam an than” extract in animals. Vietnam Medical Journal. 2017; 10(2): 215-219.
6. Alicia A Walf, Cheryl A Frye. The use of the elevated plus maze as an assay of anxiety-related behavior in rodents. Nature protocols. 2007; 2(2): 322-328.
7. Hiromi Shiotsuki, Kenji Yoshimi, Yasushi Shimo et al. A rotarod test for evaluation of motor skill learning. Journal of Neuroscience Methods. 2010; 189(2): 180-185.
8. Robert M.J. Deacon. Measuring Motor Coordination in Mice. Journal of Visualized Experiments. 2013; 75(e2609): 1-8.
9. Alline C. Campos, Manoela V. Fogac, Daniele C. Aguiar. Animal models of anxiety disorders and stress. Revista Brasileira de Psiquiatria. 2013; 35: S101–S111.
10. Luciana M. Leo, Fabricio A. Pamplona. Elevated Plus Maze Test to Assess Anxiety-like Behavior in the Mouse. Bio-protocol. 2014; 4(6): 1-8.
11. Hikari Takeshita, Koichi Yamamoto, Satoko Nozato et al. Modified forelimb grip strength test detects aging-associated physiological decline in skeletal muscle function in male mice. Scientific reports. 2017; 7(42323): 1-9.
12. Rui Shi, Yan Han, Yu Yan et al. Loganin Exerts Sedative and Hypnotic Effects via Modulation of the Serotonergic System and GABAergic Neurons. Frontiers in Pharmacology. 2019; 10(409): 1-11.
13. Huai-Syuan Huang, Hsin-Yu Wu, Wan-Ting Chang et al. The Antidepressive and Anxiolytic Effects of Formula Consisted of Poria cocos and Cordyceps militaris Waster Medium Extract in Unpredictable Chronic Mild Stress Animal Model. Current Developments in Nutrition. 2020; 4(2): 1212.
14. Wen-Huang Peng, Ming-Tsuen Hsieh, Yi-Shung Lee et al. Anxiolytic effect of seed of Ziziphus jujuba in mouse models of anxiety. Journal of Ethnopharmacology. 200; 72: 435-441.
15. Bombi Lee, Bongjun Sur, Seunghwan Shin et al. Polygala tenuifolia prevents anxiety-like behaviors in mice exposed to repeated restraint stress. Animal Cells and Systems. 2015; 19(1):1-7.
16. Yi Yao, Min Jia, Jian-Guo Wu et al. Anxiolytic and sedative-hypnotic activities of polygalasaponins from Polygala tenuifolia in mice. Pharmaceutical Biology. 2010; 48(7): 801-7.
17. Muzalfa Arooj, Saira Imran, Muhammad Inam-ur-Raheem et al. Lotus seeds (Nelumbinis semen) as an emerging therapeutic seed: A comprehensive review. Food Science and Nutrition. 2021; 9: 3971-3987.
18. Sa-Ik Hong, Seung-Hwan Kwon, Min-Jung Kim et al. Anxiolytic-Like Effects of Chrysanthemum indicum Aqueous Extract in Mice: Possible Involvement of GABAA Receptors and 5-HT1A Receptors. Biomolecules and Therapeutics. 2012; 20(4): 413-417.