8. The association between metabolic syndrome and hand osteoarthritis in individuals over 40 years old
Main Article Content
Abstract
This cross-sectional study aimed to evaluate the association between metabolic syndrome and radiographichand osteoarthritis in individuals over 40 years old. 442 volunteers at and over 40 years old participated in the Vietnam Osteoporosis Study from February 2024 to June 2024. Overall, the prevalence of radiographic hand osteoarthritis in individuals over 40 years old was 20.36%. This prevalence was significantly higher in individuals with metabolic syndrome compared to those without syndrome (32.90% vs 13.59%; p < 0.001). Metabolic syndrome was statistically significantly associated with radiographic hand osteoarthritis, with an OR of 1.85 (95% CI: 1.05 – 3.25) after adjusting for confounding factors. Additionally, increased waist circumference and hyperglycemia were also associated with radiographic hand osteoarthritis with ORs of 2.06 (95% CI: 1.14 – 3.71) and 2.24 (95% CI: 1.25 – 4.02), respectively.
Article Details
Keywords
Hand osteoarthritis, metabolic syndrome, radiograph
References
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19. Loef M, Schoones JW, Kloppenburg M, Ioan-Facsinay A. Fatty acids and osteoarthritis: different types, different effects. Joint Bone Spine. 2019; 86(4): 451-458. doi:10.1016/j.jbspin.2018.07.005.
2. Plotz B, Bomfim F, Sohail MA, Samuels J. Current Epidemiology and Risk Factors for the Development of Hand Osteoarthritis. Curr Rheumatol Rep. 2021; 23(8):61. doi:10.1007/s11926-021-01025-7.
3. Marshall M, Watt FE, Vincent TL, Dziedzic K. Hand osteoarthritis: clinical phenotypes, molecular mechanisms and disease management. Nat Rev Rheumatol. 2018; 14(11): 641-656. doi:10.1038/s41584-018-0095-4.
4. Kolasinski SL, Neogi T, Hochberg MC, et al. 2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee. Arthritis Rheumatol. 2020; 72(2): 220-233. doi:10.1002/art.41142.
5. Dickson BM, Roelofs AJ, Rochford JJ, Wilson HM, De Bari C. The burden of metabolic syndrome on osteoarthritic joints. Arthritis Res Ther. 2019; 21(1): 289. doi:10.1186/s13075-019-2081-x.
6. Wei G, Lu K, Umar M, et al. Risk of metabolic abnormalities in osteoarthritis: a new perspective to understand its pathological mechanisms. Bone Res. 2023; 11(1):63. doi:10.1038/s41413-023-00301-9.
7. Eaton CB, Roberts M, Lu B, Lo G, Driban JB, McAlindon TE. Cross-sectional association of metabolic syndrome and abdominal adiposity with hand osteoarthritis: results from the osteoarthritis initiative. Osteoarthritis and Cartilage. 2014; 22:S212-S213. doi:10.1016/j.joca.2014.02.407
8. Altman RD, Gold GE. Atlas of individual radiographic features in osteoarthritis, revised. Osteoarthritis and Cartilage. 2007; 15:A1-A56. doi:10.1016/j.joca.2006.11.009.
9. Bijsterbosch J, Haugen IK, Malines C, et al. Reliability, sensitivity to change and feasibility of three radiographic scoring methods for hand osteoarthritis. Annals of the Rheumatic Diseases. 2011; 70(8): 1465-1467. doi:10.1136/ard.2010.143479.
10. Paradowski PT, Lohmander LS, Englund M. Natural history of radiographic features of hand osteoarthritis over 10 years. Osteoarthritis and Cartilage. 2010; 18(7): 917-922. doi:10.1016/j.joca.2010.04.008.
11. Alberti KGMM, Eckel RH, Grundy SM, et al. Harmonizing the Metabolic Syndrome: A Joint Interim Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation. 2009; 120(16): 1640-1645. doi:10.1161/CIRCULATIONAHA.109.192644.
12. Strand MP, Neogi T, Niu J, Felson DT, Haugen IK. Association Between Metabolic Syndrome and Radiographic Hand Osteoarthritis: Data From a Community-Based Longitudinal Cohort Study. Arthritis Care Res. 2018; 70(3): 469-474. doi:10.1002/acr.23288.
13. Kodama R, Muraki S, Oka H, et al. Prevalence of hand osteoarthritis and its relationship to hand pain and grip strength in Japan: The third survey of the ROAD study. Modern Rheumatology. 2016; 26(5):767-773. doi:10.3109/14397595.2015.1130673.
14. Visser AW, De Mutsert R, Le Cessie S, Den Heijer M, Rosendaal FR, Kloppenburg M. The relative contribution of mechanical stress and systemic processes in different types of osteoarthritis: the NEO study. Ann Rheum Dis. 2015; 74(10): 1842-1847. doi:10.1136/annrheumdis-2013-205012.
15. Sanchez-Santos M, Judge A, Gulati M, et al. Association of metabolic syndrome with knee and hand osteoarthritis: A community-based study of women. Seminars in Arthritis and Rheumatism. 2019; 48(5): 791-798. doi:10.1016/j.semarthrit.2018.07.007.
16. Mohajer B, Kwee RM, Guermazi A, et al. Metabolic Syndrome and Osteoarthritis Distribution in the Hand Joints: A Propensity Score Matching Analysis From the Osteoarthritis Initiative. J Rheumatol. 2021; 48(10): 1608-1615. doi:10.3899/jrheum.210189.
17. Marshall M, Peat G, Nicholls E, Myers H, Mamas M, Van Der Windt D. Metabolic risk factors and the incidence and progression of radiographic hand osteoarthritis: a population-based cohort study. Scandinavian Journal of Rheumatology. 2019; 48(1): 52-63. doi:10.1080/03009742.2018.1459831.
18. Courties A, Berenbaum F, Sellam J. The Phenotypic Approach to Osteoarthritis: A Look at Metabolic Syndrome-Associated Osteoarthritis. Joint Bone Spine. 2019; 86(6): 725-730. doi:10.1016/j.jbspin.2018.12.005.
19. Loef M, Schoones JW, Kloppenburg M, Ioan-Facsinay A. Fatty acids and osteoarthritis: different types, different effects. Joint Bone Spine. 2019; 86(4): 451-458. doi:10.1016/j.jbspin.2018.07.005.