4. Nghiên cứu đặc điểm một số biến thể gen microRNA-146a và mối liên quan với mức độ nặng lâm sàng của người bệnh nhồi máu cơ tim cấp

Abstract

As MicroRNA-146a plays an important role in inflammation and fibrosis, single nucleotide polymorphisms of this gene have been reported to be associated with the severity of acute myocardial infarction. This study was conducted to evaluate MicroRNA-146a gene polymorphisms and their association with clinical severity in patients with acute myocardial infarction. This is a cross-sectional study of a total of 130 patients with acute myocardial infarction compared with 130 controls who came to Can Tho Central General Hospital and Can Tho University of Medicine and Pharmacy Hospital for examination and treatment from May 2023 to November 2024. All patients had their clinical information collected and gene sequencing was performed to identify variants rs2431697, rs57095329, rs2910164. 70.0% of patients were male, average age were 65.2 ± 11.0 years old. Results showed that the TC + CC genotype of rs2431697 were higher in frequency compared to the control group, with 30.0% compared to 19.2%; similarly, the CG + GG genotype of rs2910164 was also higher in frequency compared to the control group, 63.8% compared to 48.5%. The factors such as rs2431697 allele C (OR = 11.94), rs2910164 allele G (OR = 5.81), dyslipidemia (OR = 3.47) were independent risk factors of clinically severe acute myocardial infarction. In conclusion, the study suggests that the C risk allele of rs2431697 and G risk allele of rs2910164 of microRNA-146a gene together with dyslipidemia, are important factors that increase the risk of clinically severe myocardial infarction.