Lupus ban đỏ hệ thống ở nam giới: Nghiên cứu mô tả cắt ngang tại trung tâm dị ứng miễn dịch lâm sàng, Bệnh viện Bạch Mai

Abstract

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects multiple organs and is more commonly seen in females. Meanwhile, SLE in males has not received adequate attention due to its significantly lower prevalence. In Vietnam, there are very few separate reports focusing on SLE in males. We conducted a cross-sectional descriptive study at the Clinical Immunology and Allergy Center, Bach Mai Hospital, involving 55 male patients diagnosed with SLE. The results showed that males had a higher mean age at diagnosis compared to females. The prevalence of serositis and thrombocytopenia was higher in males, whereas skin rashes and arthritis were more common in females. Lupus nephritis was observed in 50.9% of cases and was associated with younger age, higher disease activity, lower eGFR, and decreased C3 levels. There was no significant difference in the presence of specific autoantibodies between patients with and without renal involvement. These data provide insights to guide more appropriate strategies for diagnosis, monitoring, and treatment of male lupus patients in Vietnam.