Đánh giá ảnh hưởng của axit tranexamic trên một số xét nghiệm đông cầm máu ở bệnh nhân phẫu thuật cột sống do lao

Abstract

This study aimed to evaluate the effect of tranexamic acid (TXA) on selected coagulation parameters in patients undergoing spinal surgery for tuberculosis-related pathology. A randomized, double-blind, controlled clinical trial was conducted on 60 patients at the National Lung Hospital from August 2023 to September 2024, divided equally into a TXA group and a control group. Coagulation parameters, including platelet count, prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen, and D-dimer, were measured before and after surgery. The results showed that the reduction in platelet count was less pronounced in the TXA group (273.6 ± 73.8 G/L) compared with the control group (238.6 ± 55.3 G/L; p < 0.05). Postoperative increases in PT, APTT, and fibrinogen were significantly smaller in the TXA group (p < 0.01). Notably, D-dimer levels increased markedly after surgery in the TXA group, whereas they slightly decreased in the control group (p < 0.01). These findings suggest that TXA helps stabilize coagulation status in spinal tuberculosis surgery but warrants close monitoring for potential venous thromboembolism risk in postoperative patients receiving TXA.