Some factors related to mortality among large-core ischemic stroke patients due to anterior cerebral circulation occlusion received thrombectomy within 6 hours
Main Article Content
Abstract
The study aimed to identify factors related to mortality among large-core ischemic stroke patients who underwent anterior cerebral circulation thrombectomy within 6 hours. A retrospective observational study was conducted at the Stroke Center from May 2024 to May 2025. Clinical, paraclinical, and imaging characteristics were collected and analyzed. Univariate and multivariate regression analyses were used to identify factors associated with mortality. The results of the study on 66 patients showed that the mean age of the patient group was 65 years; 62.1% were male; the median admission NIHSS scores were 12 (IQR 10 - 16); The rates of successful recanalization and symptomatic hemorrhagic transformation were 72.7% and 24.2%, respectively. The mortality rate at day 90 was 31.3%. Univariate and multivariate analyses showed that re-occlusion within 24 hours after intervention (OR 12.273; 95% CI: 2.321 - 64.904) and a decrease in NIHSS score by > 4 points (OR 0.208; 95% CI: 0.045 - 0.960) were associated with mortality.
Article Details
Keywords
Large core infarction, anterior circulation occlusion, mechanical thrombectomy, mortality
References
2. Mai Duy Tôn, Đào Việt Phương, Nguyễn Tiến Dũng, et al. Sex disparity in stroke outcomes in a multicenter prospective stroke registry in Vietnam. Int J Stroke. 2023; 18(9): 1102-1111. doi:10.1177/17474930231177893.
3. Goyal M, Menon BK, Zwam WH van, et al. Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials. The Lancet. 2016; 387(10029): 1723-1731. doi:10.1016/S0140-6736(16)00163-X.
4. Khan F, Yogendrakumar V, Menon BK. Endovascular Thrombectomy for Ischemic Stroke With Large Infarct. Stroke. 2025; 56(6): 1655-1658. doi:10.1161/STROKEAHA.125.050897.
5. Von Kummer R, Broderick JP, Campbell BCV, et al. The Heidelberg Bleeding Classification. Stroke. 2015; 46(10): 2981-2986. doi:10.1161/STROKEAHA.115.010049.
6. Yoshimura S, Sakai N, Yamagami H, et al. Endovascular Therapy for Acute Stroke with a Large Ischemic Region. New England Journal of Medicine. 2022; 386(14): 1303-1313. doi:10.1056/NEJMoa2118191.
7. Huo X, Ma G, Tong X, et al. Trial of Endovascular Therapy for Acute Ischemic Stroke with Large Infarct. New England Journal of Medicine. 2023; 388(14): 1272-1283. doi:10.1056/NEJMoa2213379.
8. Sarraj A, Hassan AE, Abraham MG, et al. Trial of Endovascular Thrombectomy for Large Ischemic Strokes. New England Journal of Medicine. 2023; 388(14): 1259-1271. doi:10.1056/NEJMoa2214403.
9. Thomalla G, Fiehler J, Subtil F, et al. Endovascular thrombectomy for acute ischaemic stroke with established large infarct (TENSION): 12-month outcomes of a multicentre, open-label, randomised trial. The Lancet Neurology. 2024; 23(9): 883-892. doi:10.1016/S1474-4422(24)00278-3.
10. Broocks G, McDonough R, Bechstein M, et al. Benefit and risk of intravenous alteplase in patients with acute large vessel occlusion stroke and low ASPECTS. J Neurointerv Surg. 2023; 15(1): 8-13. doi:10.1136/neurintsurg-2021-017986.
11. Panni P, Gory B, Xie Y, et al. Acute Stroke With Large Ischemic Core Treated by Thrombectomy. Stroke. 2019; 50(5): 1164-1171. doi:10.1161/STROKEAHA.118.024295.