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Published: 2025-12-30
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DOI: https://doi.org/10.52852/tcncyh.v197i12.4357
Issue
Vol. 197 No. 12 (2025)
Section
Các bài báo
How to Cite
Anh, P. T. V., Lan, V. T., Dưỡng, N. C., Vân, N. T., Huy, V. Q., & Loan, N. T. T. (2025). Experimental study on the fibrinolytic effect of Tri Bao Hoan. Journal of Medical Research, 197(12), 516-525. https://doi.org/10.52852/tcncyh.v197i12.4357

Experimental study on the fibrinolytic effect of Tri Bao Hoan

Pham Thi Van Anh, Vu Thi Lan, Nguyen Chi Duong, Nguyen Trieu Van, Vu Quang Huy, Nguyen Thi Thanh Loan

Main Article Content

Abstract

This study aimed to evaluate the fibrinolytic effects of Tri Bao Hoan using a thrombin-induced blood coagulation model in rabbits. Blood coagulation was induced by gradually injecting thrombin solution (15 IU/rabbit) into the marginal ear vein. Coagulation parameters, including prothrombin time (PT), activated partial thromboplastin time (aPTT), and D-dimer concentration, were measured to assess the effects of Tri Bao Hoan on coagulation and fibrinolysis. Additionally, serum AST and ALT, along with creatinine and urea levels, were measured to evaluate potential hepatocellular injury and renal function. Tri Bao Hoan did not affect coagulation parameters in normal rabbits. In the thrombin-induced coagulation model, Tri Bao Hoan at 0.06 tablet/kg/day showed no significant fibrinolytic activity, whereas the 0.18 tablet/kg/day dose significantly increased D-dimer levels and prolonged aPTT compared to the control group (p < 0.05). Neither dose of Tri Bao Hoan caused significant changes in body weight, AST, ALT, urea, or creatinine levels. In conclusion, Tri Bao Hoan at 0.18 tablet/kg/day exhibited fibrinolytic effects in a thrombin-induced coagulation model in rabbits.

Article Details

Keywords

Tri Bao Hoan, fibrinolysis, experimental animals

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