Incidental diagnosis of von Hippel - Lindau syndrome revealed by new-onset diabetes mellitus
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Abstract
Von Hippel - Lindau (VHL) syndrome is a rare autosomal dominant hereditary disorder caused by mutations in the VHL gene. It is characterized by the occurrence of tumors in multiple organs. Pancreatic involvement in VHL syndrome can present as pancreatic cysts or neuroendocrine tumors, potentially affecting endocrine pancreatic functions. We report a case of a young female patient newly diagnosed with diabetes mellitus, with dectection of multiple pancreatic cysts. Further imaging studies revealed a pancreatic neuroendocrine tumor and bilateral renal cell carcinomas. Clinical, genetic (mutation of the VHL gene) and imaging findings led to the diagnosis of Von Hippel - Lindau syndrome. This case highlights the importance of comprehensive evaluation when encountering atypical pancreatic lesions in patients with newly diagnosed diabetes mellitus.
Article Details
Keywords
Von Hippel - Lindau, đái tháo đường mới phát hiện, u thần kinh nội tiết tụy, ung thư thận
References
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