Anticoagulant effect of Tri Bao Hoan in an experimental thrombosis model
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Tóm tắt
The purpose of this study was to evaluate the anticoagulant effects of Tri Bao Hoan in a lipopolysaccharide (LPS)-induced thrombosis model using Wistar rats. Tri Bao Hoan and rivaroxaban were administered orally for seven consecutive days. One hour after the final dose, LPS (3 mg/kg) was injected via the tail vein to induce thrombosis. Blood samples were collected four hours after LPS administration to assess the study parameters. Our findings indicated that Tri Bao Hoan at 0.36 pill/kg/day exerted significant anticoagulant effects by increasing platelet count and fibrinogen concentration, as well as prolonging prothrombin time (PT) and activated partial thromboplastin time (aPTT) compared with the vehicle-treated thrombosis group (p < 0.05). Tri Bao Hoan at 0.12 pill/kg/day did not show statistically significant changes in these parameters (p > 0.05). Regarding biochemical findings, Tri Bao Hoan at 0.36 pill/kg/day significantly reduced serum AST activity in the vehicle-treated thrombosis group (p < 0.05), whereas AST activity, urea and creatinine concentration remained statistically unchanged at both doses (p > 0.05). In conclusion, Tri Bao Hoan at 0.36 pill/kg/day demonstrated a significant anticoagulant effect in Wistar rats with LPS-induced thrombosis.
Chi tiết bài viết
Từ khóa
Tri Bao Hoan, anticoagulant effect, lipopolysaccharide, Wistar rats
Tài liệu tham khảo
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