Survey of GFAP and UCH-L1 concentrations in patients with mild traumatic brain injury at Thai Nguyen Central General Hospital
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Abstract
Traumatic brain injury (TBI) is one of the leading causes of mortality and disability in Vietnam. This study assessed the concentrations of glial fibrillary acidic protein (GFAP) and ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1) in patients with mild TBI. This was a cross-sectional descriptive study performed on 146 patients with mild TBI and 30 healthy individuals. The results showed that the median concentrations of GFAP and UCH-L1 in the mild TBI group were 105.47 pg/mL and 456.38 pg/mL, respectively, which were higher than the healthy control group. Based on Boolean algorithm analysis, all healthy participants tested negative, while the positivity rate in the mild TBI group was 84.25%. GFAP and UCH-L1 concentrations in mild TBI patients injured by traffic accidents were higher than other injury mechanisms, with a statistically significant difference (p < 0.05). In contrast, differences between patients admitted within 6 hours versus 6 - 12 hours post-injury, and between those with GCS 13–14 and GCS 15, were not statistically significant (p > 0.05).
Article Details
Keywords
Traumatic brain injury, GFAP, UCH-L1
References
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