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Published: 2026-01-28
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DOI: https://doi.org/10.52852/tcncyh.v198i1.4491
Issue
Vol. 198 No. 1 (2026)
Section
Các bài báo
How to Cite
Minh, N. T., Nguyệt, Đặng T. M., Đức, L. T., Minh, N. H. H., & Hưng, M. T. (2026). Changes in AMH concentration immediately after chemotherapy in women with non-metastatic primary breast cancer and associated factors. Journal of Medical Research, 198(1), 339-346. https://doi.org/10.52852/tcncyh.v198i1.4491

Changes in AMH concentration immediately after chemotherapy in women with non-metastatic primary breast cancer and associated factors

Nguyen Tuan Minh, Dang Thi Minh Nguyet, Le Thanh Duc, Nguyen Huu Hoàng Minh, Mai Trong Hung

Main Article Content

Abstract

A prospective, longitudinal descriptive study comparing pre-chemotherapy and immediately post-chemotherapy levels was conducted on 97 women with non-metastatic breast cancer, aged 25 - 45 years, at K Hospital during 2024 - 2025, to determine the change in AMH concentration immediately after chemotherapy in women with non-metastatic primary breast cancer. AMH concentrations significantly decreased from baseline (AMH0) to nearly undetectable levels immediately after chemotherapy (AMH1; p < 0.0001), regardless of age, BMI status, menstrual status, number of children, histopathological characteristics, immunohistochemical status, or the timing or regimen of chemotherapy. Thus, chemotherapy for breast cancer induces a near-total depletion of the functional ovarian reserve immediately after its completion.

Article Details

Keywords

Anti-Müllerian Hormone (AMH), Breast cancer, Chemotherapy, Gonadotoxicity

References

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