Đánh giá tác dụng bảo vệ gan của dền toòng quả dài (gomphogyne bonii gagnep.) trên động vật thực nghiệm

Abstract

The liver is a vital organ which performs numerous essential roles in the body. Liver diseases can result from a variety of causes. This study evaluated the hepatoprotective effect of Gomphogyne bonii Gagnep. (DTQD) on experimental animal. Swiss mice were divided into five groups. The animals were administered for ten consecutive days with DTQD (4 g/kg/day and 12 g/kg/day), silymarin (140 mg/kg), and CMC 0,5% solution. On the 10th day, after 2 hours of administration of DTQD (4 g/kg/day and 12 g/kg/day), liver cell damage was initiated by paracetamol at 400 mg/kg. The evaluated indicators included liver weight, AST and ALT levels, as well as gross and microscopic evaluation of the mice's liver tissue. The results showed that both doses of DTQD (4 g/kg/day and 12 g/kg/day) significantly reduced AST and ALT activities compared with the model group. Both doses decreased liver weight and improved gross and histological liver parameters. Notably, the 4 g/kg/day dose exhibited greater efficacy than the 12 g/kg/day dose. In conclusion, DTQD demonstrated a protective effect in the paraceramol-induced acute hepatitis in Swiss mice.