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Published: 2026-03-09
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DOI: https://doi.org/10.52852/tcncyh.v199i2.4660
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Vol. 199 No. 2 (2026)
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Lê, N. N. Q., Dương, Đặng Ánh, Ngọc, C. T. B., Phương Anh, H. ., Hạnh, V. T., Thúy, T. T., Bình, N. T., Dũng, V. C., & Tùng, C. V. (2026). Allogeneic Hematopoietic Stem Cell Transplantation Combined with Disseminated Infection by Trichosporon Asahii: A Case Study. Journal of Medical Research, 199(2), 753-760. https://doi.org/10.52852/tcncyh.v199i2.4660

Allogeneic Hematopoietic Stem Cell Transplantation Combined with Disseminated Infection by Trichosporon Asahii: A Case Study

Nguyen Ngoc Quynh Le, Dang Anh Duong, Can Thi Bich Ngoc, Ha Phuong Anh, Vu Thi Hanh, Tong Thi Thuy, Nguyen Thanh Binh, Vu Chi Dung, Cao Viet Tung

Main Article Content

Abstract

Invasive fungal infection is a serious complication of allogeneic hematopoietic stem cell transplantation, with a high mortality rate, but data in pediatric population is limited. The most common fungal pathogens are Candida and Aspergillus; however, some other rare fungal pathogens can cause severe clinical manifestation. We describe a case of catheter-related T. asahii bloodstream infection of the 24-month-old boy who was in the neutropenic period after allogeneic stem cell transplantation for Mucopolysaccharidoses type 2. We successfully treated him with intravenous voriconazol and a second haploidentical stem cell transplantation without any serious complications due to fungal infection. Clinicians should consider the possibility of Trichosporin infections in neutropenic patients if symptoms do not improve despite proper treatment with various antibiotics and/or antifungal agents.

Article Details

Keywords

Invasive fungal infection, Trichosporon asahi, Neutropenia, Allogeneic hematopoietic stem cell transplantation

References

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