Survival outcomes and prognostic factors in early-stage (I–II) oral tongue cancer in female patients at K Hospital

Ngo Quoc Duy, Mai Van Chinh

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Abstract

Oral tongue cancer is one of the most common malignancies of the oral cavity. The treatment of tongue cancer is multimodal, in which surgery plays a central role, particularly in patients with stage I-II disease. This study was a retrospective–prospective analysis of 91 female patients diagnosed with stage I-II oral tongue squamous cell carcinoma who were treated at K Hospital between January 2018 and December 2024. Surgery was the primary treatment modality in all patients (100%). Surgery alone accounted for 86.8%, followed by 13.2% of surgery combined with adjuvant radiotherapy or chemoradiotherapy. The median follow-up duration was 33.5 months (range: 6 - 78 months). Disease recurrence was observed in 9.9% of patients after treatment. The 3-year overall survival (OS) and 3-year disease-free survival (DFS) rates were 96.7% and 90.6%, respectively. Histological grade, depth of invasion, and disease stage were identified as important prognostic factors. Therefore, a combination of treatment modalities should be considered to improve overall survival and disease-free survival in patients presenting with these adverse prognostic factors.

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References

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