Embryo development outcomes from vitrified - warmed oocytes at Hanoi General Hospital
Main Article Content
Abstract
This retrospective descriptive study was conducted on 203 females whose oocytes underwent vitrification, warming, and in vitro fertilization, involving a total of 1,623 oocytes (including 573 fresh oocytes and 1,050 cryopreserved oocytes) at the Infertility and Medical Sexology Center, Hanoi General Hospital, from July 2023 to July 2025. The study aimed to evaluate embryological outcomes of vitrified oocytes and to investigate the association between female age, as well as the duration of oocyte storage in liquid nitrogen, and the effectiveness and safety of oocyte cryopreservation. The results showed that the post-warming oocyte survival rate, fertilization rate, day-3 cleavage-stage embryo formation rate, blastocyst rate, and usable blastocyst rate were 96.31%, 85.39%, 85.58%, 56.27%, and 35.75%, respectively. In the oocyte accumulation group, there was no statistically significant difference in fertilization rate, blastocyst formation rate, or usable blastocyst rate between fresh and warmed oocytes (p > 0.05); however, the day-3 cleavage-stage embryo formation rate was significantly higher in the fresh oocyte group compared with the warmed oocyte group (p = 0.031). Additionally, there was no significant association between female age or duration of cryostorage and post-warming oocyte survival, fertilization rate, or embryo developmental outcomes (p > 0.05). These preliminary findings indicate that oocyte vitrification is a safe and effective technique.
Article Details
Keywords
Oocyte cryopreservation, Oocyte vitrification, Fertilization rate, Embryo formation rate
References
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