Disease patterns of allergic inpatients at the department of allergy, immunology and dermatology, E Hospital from 2020- 2025

Bui Van Dan, Nguyen Le Ha, Pham Thi Huyen

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Abstract

Investigating disease spectrum plays a core role in evaluating healthcare capacity and guiding strategic professional development. A retrospective descriptive study was conducted on 3,029 medical records to analyze the characteristics and spectrum of allergic diseases among inpatients at the Department of Allergy, Immunology and Dermatology, E Hospital, over a 5-year period (June 2020 - May 2025). Results revealed a female predominance, representing 58.57%. The mean age of the study population was 47.36 ± 22.06 years old,  where 35.99% was > 60 years old. Hospital admissions and total inpatient days exhibited an upward trend over the years (particularly in the post-COVID-19 period), accompanied by a significant increase in the proportion of out-of-province patients from 11.61% to 31.25% (p < 0.001). Regarding the disease spectrum, urticaria and angioedema were the most prevalent diagnoses (40.31%), followed by delayed hypersensitivity reactions (16.21%). Treatment outcomes showed that 99.77% of patients achieved clinical remission upon discharge. The number of inpatients with urticaria and angioedema increased during summer and autumn, whereas spring was the peak admission season for asthma and antibiotic allergies (p < 0.05). Multivariate regression analysis identified age, delayed hypersensitivity reactions (IRR = 1.84), antibiotic allergies (IRR = 1.71), asthma (IRR = 1.40), and atopic dermatitis (IRR = 1.35) as independent factors prolonging the length of hospital stay (p < 0.05). The average length of stay was 6.99 ± 6.06 days, with anti-tuberculosis drug allergies requiring the longest hospitalization. Hospital admissions and total inpatient days exhibited an upward trend over the years (particularly in the post-COVID-19 period), accompanied by a steady increase in the proportion of out-of-province patients from 11.61% to 31.25%.

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References

1. Shin YH, Hwang J, Kwon R, et al. Global, regional, and national burden of allergic disorders and their risk factors in 204 countries and territories, from 1990 to 2019: A systematic analysis for the Global Burden of Disease Study 2019. Allergy. 2023; 78(8): 2232-2254. doi:10.1111/all.15807.
2. Aldakheel FM. Allergic Diseases: A Comprehensive Review on Risk Factors, Immunological Mechanisms, Link with COVID-19, Potential Treatments, and Role of Allergen Bioinformatics. Int J Environ Res Public Health. 2021; 18(22): 12105. doi:10.3390/ijerph182212105.
3. Nguyễn Thị Thuỳ Ninh, Nguyễn Văn Đoàn. Đặc điểm lâm sàng và kết quả điều trị phản vệ ở Bệnh viện đa khoa Tâm Anh Hà Nội. Tạp chí Y học Việt Nam. 2024; 535(1). doi:10.51298/vmj.v535i1.8346.
4. Nguyễn Thị Kim Cúc, Lê Huyền My, Chu Nhật Uyên, và cs. Sự khác biệt về đặc điểm lâm sàng và xét nghiệm giữa các thể mày đay mạn tính tại Việt Nam. Tạp chí Nghiên cứu Y học. 2025; 191(6): 209-216. doi:10.52852/tcncyh.v191i6.3505.
5. Trần Thị Phương Chi, Hoàng Thị Lâm. Tình trạng tổn thương gan do dị ứng thuốc tại bệnh viện Đà Nẵng. Tạp chí Y học Việt Nam. 2023; 521(2). doi:10.51298/vmj.v521i2.4103.
6. Yim Y, Jo H, Park S, et al. Sex-Specific and Long-Term Trends of Asthma, Allergic Rhinitis, and Atopic Dermatitis in South Korea, 2007-2022: A Nationwide Representative Study. Int Arch Allergy Immunol. Published online September 16, 2024: 1-18. doi:10.1159/000540928.
7. Fuseini H, Newcomb DC. Mechanisms Driving Gender Differences in Asthma. Curr Allergy Asthma Rep. 2017; 17(3): 19. doi:10.1007/s11882-017-0686-1.
8. Borrelli R, Brussino L, Lo Sardo L, et al. Sex-Based Differences in Asthma: Pathophysiology, Hormonal Influence, and Genetic Mechanisms. Int J Mol Sci. 2025; 26(11): 5288. doi:10.3390/ijms26115288.
9. Nguyễn Ngọc Hân, Nguyễn Thị Hồng Minh, Đỗ Thị Thanh Trà. Kết quả kiểm soát hen phế quản và một số yếu tố liên quan đến kiểm soát hen phế quản không hoàn toàn. Tạp chí Dược học Cần Thơ. 2024; (74): 126-131. doi:10.58490/ctump.2024i74.2551.
10. Alpagat G, Kalpaklioglu AF, Baccioglu A. Impact of Seasonal, Environmental, and Inflammatory Factors on Chronic Urticaria Activity and Serum Biomarkers: A Prospective Cohort Study. J Clin Med. 2026; 15(2): 645. doi:10.3390/jcm15020645.
11. Nguyen Thi Trang Nhung, Schindler C, Dien TM, et al. Acute effects of ambient air pollution on lower respiratory infections in Hanoi children: An eight-year time series study. Environ Int. 2018; 110: 139-148. doi:10.1016/j.envint.2017.10.024.
12. Birkmeyer JD, Barnato A, Birkmeyer N, et al. The Impact Of The COVID-19 Pandemic On Hospital Admissions In The United States: Study examines trends in US hospital admissions during the COVID-19 pandemic. Health Aff (Millwood). 2020; 39(11): 2010-2017. doi:10.1377/hlthaff.2020.00980.
13. Oh J, Lee M, Kim M, et al. Incident allergic diseases in post-COVID-19 condition: multinational cohort studies from South Korea, Japan and the UK. Nat Commun. 2024; 15(1): 2830. doi:10.1038/s41467-024-47176-w.