Anemia associated with stages and Child-Pugh in of HBV infection-related hepatocellular carcinoma
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Abstract
A cross-sectional descriptive study was conducted in 100 HCCB patients to evaluate the association between anemia and disease stages as well as Child–Pugh class in patients with chronic hepatitis B virus (HBV) infection-related hepatocellular carcinoma (HCC) (HCCB). The prevalence of anemia increased progressively from 20 – 26% in Child–Pugh class A to 56 – 72% in class B and 83 – 100% in class C. Anemia prevalence also rose with advancing BCLC stage, with reduced erythrocyte indices observed in 23.68% of patients with stage A-HCCB, 33.33% of patients with stage B-HCCB, 42.42% of patients with stage C-HCCB, and 100% of patients with stage D-HCCB (p < 0.05). Erythrocyte indices (RBC, HGB, and HCT) declined progressively from Child–Pugh class A to C and from BCLC stage A to D (p < 0.05). Both the prevalence and severity of anemia increased in parallel with worsening Child–Pugh class and advancing BCLC stage, independent of age and gender. These findings are inconsistent with the stimulating effect of erythropoietin-like substances secreted by HCC cells, and they highlight the need for extra study to clarify anemia status and the role of erythropoietin-like substances in anemia in patients with HBV-related HCC.
Article Details
Keywords
Anemia, Hepatocellular carcinoma (HCC), HBV, Child-Pugh, HCC Stage
References
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