Mối liên quan giữa đa hình rs1800629 gen TNFα với SIRS và điểm BISAP ở người bệnh viêm tụy cấp

Abstract

Acute pancreatitis is a clinically heterogeneous disease, and some patients may rapidly progress to severe illness. This analytical cross-sectional study was conducted on 58 patients with acute pancreatitis to investigate the association between the TNFα rs1800629 polymorphism and systemic inflammatory response syndrome (SIRS) as well as BISAP scores in patients at Tay Ninh General Hospital from June 2025 to January 2026. The results showed that the GG genotype accounted for 62.1%, the GA genotype for 37.9%, the G allele for 81.0%, and the A allele for 19.0%; the genotype distribution was consistent with Hardy–Weinberg equilibrium. Patients carrying the GA genotype had significantly higher rates of SIRS and moderate-to-high BISAP scores than those with the GG genotype. After adjustment for potential confounders, the GA genotype remained significantly associated with both SIRS and moderate-to-high BISAP scores, whereas the A allele was associated with moderate-to-high BISAP scores. These findings suggest that the TNFα rs1800629 polymorphism is associated with certain early systemic inflammatory manifestations in patients with acute pancreatitis, including systemic inflammatory response syndrome (SIRS) and moderate-to-high BISAP scores.