Association between certain HLA class I and class II alleles and disease activity in patients with psoriatic arthritis
Main Article Content
Abstract
This cross-sectional descriptive study evaluated the association between certain HLA class I and II alleles and disease activity levels, conducted on 61 patients diagnosed with psoriatic arthritis according to CASPAR criteria; patients were diagnosed and treated at the National Hospital of Dermatology and Venereology from October 2023 to June 2024. HLA typing was performed using next-generation sequencing. Disease activity was assessed using DAPSA, VAS, CRP, swollen and tender joint counts, comparing groups with and without specific HLA alleles. The results showed that HLA-B*51 was associated with fewer tender joints and lower VAS scores, as well as a reduced rate of DAPSA >14. HLA-DRB1*16 was associated with lower VAS pain scores, while HLA-DQB1*03 was associated with higher pain scores. HLA-C*06, HLA-DPB1*104, and HLA-DQB1*03 were associated with lower CRP levels. The alleles HLA-DPB1*26 and HLA-DRB1*08 were associated with higher swollen joint counts, whereas HLA-DRB1*11 was associated with lower swollen joint counts.
Article Details
Keywords
Psoriatic arthritis, DAPSA, HLA
References
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