Mối liên quan giữa đa hình rs4950928 gen CHI3L1 và chức năng hô hấp ở người bệnh hen phế quản

Abstract

An analytical cross-sectional study was conducted on 95 patients with asthma treated at Dong Nai 2 General Hospital from June 2025 to January 2026. The results showed that the CC genotype of the CHI3L1 rs4950928 polymorphism accounted for 73.7%, the CG genotype for 26.3%, and no GG genotype was detected. The frequency of the C allele was 86.8%, whereas that of the G allele was 13.2%. The FEV1/FVC ratio tended to be lower in patients carrying the CC genotype than in those with the CG genotype, and in carriers of the C allele than in carriers of the G allele. The prevalence of airway obstruction defined as FEV1/FVC < 80% was higher in the CC group than in the CG group, at 24.3% versus 0.0%, and in C allele carriers than in G allele carriers, at 20.6% versus 0.0%, with p < 0.05. In the multivariable linear regression model, the G allele of the CHI3L1 rs4950928 polymorphism was associated with a higher FEV1/FVC ratio after adjustment for clinical factors (p = 0.008). These preliminary findings suggest that the CHI3L1 rs4950928 polymorphism may be associated with airway obstruction and reduced lung function in patients with asthma.