PON1 rs854560 polymorphism and in-hospital outcomes in patients with type 2 diabetes mellitus and ischemic stroke: A case-control study
Main Article Content
Abstract
The rs854560 polymorphism of the PON1 gene may influence paraoxonase-1 enzymatic activity and has been implicated in vascular diseases through oxidative stress mechanisms. However, the role of this variant in ischemic stroke (IS) among patients with type 2 diabetes mellitus (T2DM) remains unclear. A case-control study was conducted on 118 patients with T2DM at Dong Nai General Hospital from September 2025 to December 2025, including 58 patients with IS and 60 patients without stroke. In the IS group, the frequencies of AA, AT, and TT genotypes were 94.8%, 1.7%, and 3.4%, respectively, while the A allele frequency was 95.7%. Genotype and allele distributions did not differ between the two groups and were not associated with the risk of IS. Within the IS group, the rates of hemorrhagic transformation and composite in-hospital events were higher in patients with AT/TT genotypes compared with those with the AA genotype. Multivariable Firth logistic regression analysis showed that each additional T allele increased the odds of composite in-hospital events by 4.2-fold (95% CI: 1.21–19.03; p = 0.025). These findings suggest that the PON1 rs854560 polymorphism is not associated with the risk of ischemic stroke, but may be associated with in-hospital adverse events in patients with ischemic stroke and T2DM.
Article Details
Keywords
rs854560 polymorphism, PON1 gene, in-hospital events, ischemic stroke
References
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