Mô tả biến đổi chức năng thận và khảo sát một số yếu tố liên quan sau can thiệp nội mạch ở bệnh nhân bệnh động mạch chi dưới

Abstract

In this retrospective case-series study of 35 patients with chronic limb-threatening ischemia who underwent endovascular intervention at Thong Nhat Hospital between January 2025 and March 2025, serum creatinine and estimated glomerular filtration rate were recorded within 24 hours before the procedure and approximately 24 hours after intervention with iodixanol exposure. An exploratory assessment was also performed to examine selected factors associated with postprocedural renal function changes. The results showed that the incidence of early contrast-associated acute kidney injury within 24 hours was 5.7%, whereas the incidence of CA-AKI Moderate was 14.3%. In the between-group comparison, patients with CA-AKI Moderate had lower baseline estimated glomerular filtration rate than those without the event; however, this association did not reach statistical significance in univariable Firth logistic regression. Overall, early renal function changes after endovascular intervention should be recognized in patients with chronic limb-threatening ischemia. Given the small sample size, limited number of events, and short follow-up period, these findings should be interpreted primarily as descriptive and hypothesis-generating.