Evaluation of the therapeutic and side effects of topically applied MPP in an experimental thermal burn model
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Abstract
This study evaluated the potential dermal irritation of Medicell Plus Premium (MPP) in rabbits and the systemic effects of topical MPP administration in thermally burned Wistar rats. Skin irritation testing was conducted in accordance with OECD guidelines and ISO 10993-10 standards. Thermal burns were induced on the dorsal skin of rats using a heated metal device, followed by topical application of MPP for 21 consecutive days. Haematological parameters, biochemical indices, and histopathological features of the liver and kidneys were assessed. The results demonstrated that MPP did not induce skin irritation in rabbits. Topical administration of MPP at 0.2 mL per application, once or twice daily, did not affect haematological parameters, the degree of hepatocellular injury, or hepatic and renal function. Furthermore, histopathological examination revealed no significant differences in the microscopic architecture of the liver and kidneys between the MPP-treated groups and the biological control group. In conclusion, topical application of MPP at 0.2 mL per application, administered once or twice daily, did not produce systemic toxicity after 21 days of treatment in an experimental thermal burn model.
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Keywords
Medicell Plus Premium, burn, skin irritation, experimental animals
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