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Published: 2022-08-31
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DOI: https://doi.org/10.52852/tcncyh.v156i8.1004
Issue
Vol. 156 No. 8 (2022)
Section
Các bài báo
How to Cite
Xuân, N. T., Giao, N. Q. ., Chiều, T. V., Nam, L. H., Dung, Đặng T. N., & Chi, T. K. (2022). 4. Single nucleotide polymorphism of the oprd1 in treatment in opioid-dependent patients. Journal of Medical Research, 156(8), 28-34. https://doi.org/10.52852/tcncyh.v156i8.1004

4. Single nucleotide polymorphism of the oprd1 in treatment in opioid-dependent patients

Nguyen Thi Xuan1, Nguyen Quynh Giao, Tran Van Chieu, Le Hoang Nam, Dang Thi Ngoc Dung, Tran Khanh Chi2
1 Đại học y Hà Nội
2 Ha Noi Medical University

Main Article Content

Abstract

This study is to describe the distribution of the OPRD1 gene at SNP rs2234918, SNP rs581111, SNP rs529520 and evaluate its correlation with methadone dose in methadone maintenance therapy at Ninh Binh province. We performed a cross-sectional descriptive study of 400 patients diagnosed with dependence on opiate substances and receiving methadone maintenance treatment from March 2021 to May 2022. Single nucleotide polymorphism of the OPRD1 identified by PCR and sequencing results in: SNP rs2234918: the proportion of allele A and allele C are 69.38% and 30,62% respectively; TT genotype (48.5%), CT genotype (41.75%), CC genotype (9,75%). SNP rs581111: the proportion of allele G and allele A are 88,62% v‡ 11,38% respectively; GG genotype (79.00%), AG genotype (19.25%), AA genotype (1,75%). SNP rs529520: the proportion of allele C and allele A are 15,38% v‡ 84,62% respectively; CC genotype (73.00%), AC genotype (23,25%), AA genotype (3,75%). Opioid-dependent patients carrying allele C in SNP rs2234918 are more likely to use a high maintenance dose of methadone (≥ 90 mg/day) than those without allele C with OR = 1.556 (95%CI: 1,049-2,309). Opioid-dependent patients carrying TT genotype in SNP rs2234918 are less likely to use a high maintenance dose of methadone (≥ 90 mg/day) than those without TT genotype with OR= 0,643 (95%CI: 0,433-0,953). The identification of the genotype in the OPRD1 gene in opioid- dependent patients in methadone maintenance treatment may facilitate individualization of treatment.

Article Details

Keywords

Addiction to opiates, methadone maintenance treatment (MMT), individualization of treatment, OPRD1 gene, OPRD1 gene, SNP rs2234918, SNP rs529520, SNP rs581111

References

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