1. The evaluation of in vitro effect of double carbapenems on carbapenemase producing K. Pneumoniae isolates
Main Article Content
Abstract
The effectiveness of the combination of double carbapenems by Etest was evaluated on 50 strains of carbapenem resistant K. pneumoniae. The combination of ertapenem and meropenem showed synergic effect on the 3 of 50 strains and additional effect on 47 remaining strains, while 7 of 50 strains and 43 of 50 strains showed synergic and additional effects respectively, in the testing combination of ertapenem and imipenem. There was no antagonism observed in all 50 strains. The potential synergic effect of the combination ertapenem and imipenem tends to increase when the carbapenem MIC is low. Double carbapenems use is a prosmising treatment option for carbapenem-resistant K. pneumoniae infections.
Article Details
Keywords
K. pneumoniae, double carbapenem
References
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4. Trecarichi EM, Tumbarello M. Therapeutic options for carbapenem-resistant Enterobacteriaceae infections. Virulence. 2017;8(4):470-484.
5. Sheu CC, Chang YT, Lin SY, Chen YH, Hsueh PR. Infections caused by xarbapenem-resistant Enterobacteriaceae: An update on therapeutic options. Front Microbiol. 2019;10:80.
6. Souli M, Karaiskos I, Masgala A, Galani L, Barmpouti E, Giamarellou H. Double-carbapenem combination as salvage therapy for untreatable infections by KPC-2-producing Klebsiella pneumoniae. Eur J Clin Microbiol Infect Dis Off Publ Eur Soc Clin Microbiol. 2017;36(7):1305-1315.
7. De Pascale G, Martucci G, Montini L, et al. Double carbapenem as a rescue strategy for the treatment of severe carbapenemase-producing Klebsiella pneumoniae infections: A two-center, matched case-control study. Crit Care. 2017;21(1):173.
8. Oliva A, Gizzi F, Mascellino MT, et al. Bactericidal and synergistic activity of double-carbapenem regimen for infections caused by carbapenemase-producing Klebsiella pneumoniae. Clin Microbiol Infect Off Publ Eur Soc Clin Microbiol Infect Dis. 2016;22(2):147-153.
9. Cprek JB, Gallagher JC. Ertapenem-containing double-carbapenem therapy for treatment of infections caused by carbapenem-resistant Klebsiella pneumoniae. Antimicrob Agents Chemother. 2015;60(1):669-673.
10. Cancelli F, Oliva A, De Angelis M, Mascellino MT, Mastroianni CM, Vullo V. Role of double-carbapenem regimen in the treatment of infections due to carbapenemase producing carbapenem-resistant Enterobacteriaceae: A single-center, observational study. BioMed Res Int. 2018. doi: 10.1155/2018/2785696.
11. Mashni O, Nazer L, Le J. Critical review of double-carbapenem therapy for the treatment of carbapenemase-producing Klebsiella pneumoniae. Ann Pharmacother. 2019;53(1):70-81.
12. Poirel L, Kieffer N, Nordmann P. In vitro evaluation of dual carbapenem combinations against carbapenemase-producing Enterobacteriaceae. J Antimicrob Chemother. 2016;71(1):156-161.
13. Oliva A, Scorzolini L, Cipolla A, et al. In vitro evaluation of different antimicrobial combinations against carbapenemase-producing Klebsiella pneumoniae: The activity of the double-carbapenem regimen is related to meropenem MIC value. J Antimicrob Chemother. 2017;72(7):1981-1984.
14. Galani I, Nafplioti K, Chatzikonstantinou M, Souli M. In vitro evaluation of double-carbapenem combinations against OXA-48-producing Klebsiella pneumoniae isolates using time-kill studies. J Med Microbiol. Published online March 21, 2018. doi: 10.1099/jmm.0.000725.
15. Hsu L-Y, Apisarnthanarak A, Khan E, Suwantarat N, Ghafur A, Tambyah PA. Carbapenem-resistant Acinetobacter baumannii and Enterobacteriaceae in South and Southeast Asia. Clin Microbiol Rev. 2017;30(1):1-22.
16. Phạm Hồng Nhung, Đào Xuân Cơ, Bùi Thị Hảo. Mức độ nhạy cảm với kháng sinh của các trực khuẩn Gram âm phân lập tại Khoa Điều trị tích cực Bệnh viện Bạch Mai. Tạp chí nghiên cứu Y học. 2017;109(4).
17. Daikos GL, Markogiannakis A. Carbapenemase-producing Klebsiella pneumoniae: (When) Might we still consider treating with carbapenems?. Clin Microbiol Infect. 2011;17(8):1135-1141.
18. Couffignal C, Pajot O, Laouenan C, et al. Population pharmacokinetics of imipenem in critically ill patients with suspected ventilation-associated pneumonia and evaluation dosage regimens. Br J Clin Pharmacol. 2014;78(5):1022-1034.
19. Walther-Rasmussen J, Hoiby N. Class A carbapenemases. J Antimicrob Chemother. 2007;60(3):470-482.
20. Docquier J-D, Calderone V, De Luca F, et al. Crystal structure of the OXA-48 β-Lactamase reveals mechanistic diversity among class D carbapenemases. Chem Biol. 2009;16(5):540-547.