2. Evaluation of the influence of Tecan capsules on liver and kidney function in experimental rats
Main Article Content
Abstract
The research was conducted to evaluated the influence of Tecan capsules on liver and kidney function of experimental Wistar rats. Rats were given continuous oral administration of Tecan capsules at 93.6 mg/kg and 280.8 mg/kg during 4 weeks. Hepato-renal toxicity was assessed before, at 2 weeks and 4 weeks of taking capsules. Micro-histological images of liver and kidney were obtained at the end of the experiment. The research showed that Tecan capsules at 93.6 mg/kg and 280.8 mg/kg taken continuously during 4 weeks had no effecton AST, ALT, total bilirubin, total cholesterol, albumin, creatinine in serum and micro-histological images of the kidney. However, there was a slight change in micro-histological images of the liver in rats treated with Tecan capsules but the liver function parameters remained in the safe range. Conclusion: Tecan capsules at 93.6 mg/ kg and 280.8 mg/kg taken continuously during 4 weeks had no effect on liver function and kidney function of experimental rats.
Article Details
Keywords
Tecan capsules, liver function, kidney function, Wistar rats
References
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