32. Hypoglycemic effect of the herbal mixture extraction of Camellia chrysantha, Gynostemma pentaphyllum, Gymnema latifolium and Celastrus hindsii on type 2 diabetic mice models
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Abstract
The purpose of this study was to evaluate the hypoglycemic effect of a mixture extraction of C.chrysantha, G.pentaphyllum, G.latifolium and C.hindsii on streptozotocin - nicotinamide - induced type 2 diabetes mice. Swiss white mice were randomly allocated into 5 groups, 10 mice per group. Group 1: non-induced diabetes mice. Group 2, 3, 4, 5: diabetes was induced in mice by intraperitoneal injection of nicotinamide (NA) and streptozotocin (STZ). Mice in group 1 and group 2 were administered distilled water; in group 3, administered Metformin at a dose of 200 g/kg b.w./day; in group 4 and group 5, administered the mixture extraction at a dose of 24 g/kg b.w./day and 48 g/kg b.w./day, respectively. The total period of distilled water or reagent administration was 14 days. Data of serum glucose levels, serum insulin levels and insulin resistance indices were compared between groups. The results showed that the mixture extraction at both two doses significantly reduced the serum glucose levels, the HOMA-IR index and significantly increased the HOMA-β index, QUICKI index, DI index and the percentage of pancreas out of total body weight (compared to group 2, p < 0.05) and equivalent to group 3 (p > 0.05).
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Keywords
Camellia chrysantha, Gynostemma pentaphyllum, Gymnema latifolium, Celastrus hindsii, Diabete
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