15. Effect of Moc ty vi hard capsule in gastroesophageal reflux experimental model
Main Article Content
Abstract
Gastroesophageal reflux disease (GERD) has become a common disease with an increasing trend in the world as well as in Vietnam. The use of herbal medicinal products and supplements for treatment of GERD has been of great interest in recent years. The study was conducted to evaluate the protective management effects of hard capsule Moc ty vi (MTV) in experimental animals. Wistar rats were randomly divided into 5 group of 9 animals each: control group, GERD model group, positive control group (esmeprazol), MTV at the dose of 0.252 g/kg/day and 0.756 g/kg/day for 7 consecutive days. The model of gastroesophageal reflux disease was conducted according to the Shay model in combination with oral indomethacin 40 mg/kg 2 hours before gastric ligation. Gastric juice volume, pH, free acid and total acid of gastric juice, lesion area, esophageal index: histopathology lesions are assessed at the end of the experiment. The results for MTV at 0.252 g/kg/day and 0.756 g/kg/day reduced gastric juice volume, increased gastric pH, decreased total and free acidity as well as decreased lesion volume and esophageal index compared with the model batch, increased gastric pH while reducing total and free acidity, reduced lesion area and esophageal index compared to the GERD model group.
Article Details
Keywords
Moc ty vi, gastroesophageal reflux diseasl, Wistar rats
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