3. Serum concentration of Procalcitonin and C-Reactive Protein in patients with acute exacerbation of chronic obstructive pulmonary disease complicated with infection
Main Article Content
Abstract
This is a study on the modification of serum concentration of Procalcitonin and C Reactive Protein in 123 patients with acute exacerbation of chronic obstructive pulmonary disease complicated with infection (patient group) and 77 patients with acute exacerbation of chronic obstructive pulmonary disease without infection (control group) at the National Lung Hospital from July, 2021 to June, 2022. Results: The distribution of pathogens in the infection group was A. baumannii (27.66%), K. pneumonia (13.83%) and P. aeruginosa (12.76%)… The patient group had higher serum concentrations of PCT and CRP than the control group, at 7.30 ± 23.54 ng/ml, 76.70 ± 57.06 mg/l compare to 0.07 ± 0.12 ng/ml; 10.05 ± 10.85 mg/l with p < 0.01, p < 0.001, respectively. The levels of PCT, CRP were positively correlated with the WBC in the infection group (r = 0.502, 0.396, p < 0.001).
Article Details
Keywords
PCT, CRP, AECOPD complicated with infection
References
2. Nguyễn Viết Nhung. Dịch tễ học COPD ở Việt Nam và các biện pháp phòng và điều trị. 2009;12(24):34-39.
3. Vogelmeier CF, Criner GJ, Martinez FJ, et al. Global Strategy for the Diagnosis, Management and Prevention of Chronic Obstructive Lung Disease 2017 Report: GOLD Executive Summary. Respirol Carlton Vic. 2017;22(3):575-601. doi: 10.1111/resp.13012.
4. Menezes AMB, Perez-Padilla R, Jardim JRB, et al. Chronic obstructive pulmonary disease in five Latin American cities (the PLATINO study): A prevalence study. Lancet Lond Engl. 2005;366(9500):1875-1881. doi: 10.1016/S0140-6736(05)67632-5.
5. Seemungal TA, Donaldson GC, Paul EA, et al. Effect of exacerbation on quality of life in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1998;157(5 Pt 1):1418-1422. doi: 10.1164/ajrccm.157.5.9709032.
6. Bone RC, Balk RA, Cerra FB, et al. Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis. CHEST. 1992;101(6):1644-1655. doi: 10.1378/chest.101.6.1644.
7. Zhou W, Tan J. The expression and the clinical significance of eosinophils, PCT and CRP in patients with acute exacerbation of chronic obstructive pulmonary disease complicated with pulmonary infection. Am J Transl Res. 2021;13(4):3451-3458.
8. Li Y, Xie L, Xin S, Li K. Values of procalcitonin and C-reactive proteins in the diagnosis and treatment of chronic obstructive pulmonary disease having concomitant bacterial infection. Pak J Med Sci. 2017;33(3):566-569. doi: 10.12669/pjms.333.12554.
9. Anthonisen NR, Manfreda J, Warren CP, et al. Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease. Ann Intern Med. 1987;106(2):196-204. doi: 10.7326/0003-4819-106-2-196.
10. Sharafkhaneh A, Spiegelman AM, Main K, et al. Mortality in patients admitted for concurrent COPD exacerbation and pneumonia. COPD J Chronic Obstr Pulm Dis. 2017;14(1):23-29. doi: 10.1080/15412555.2016.1220513.
11. Huỳnh Đình Nghĩa, Trương Dương Phi, và cs. Nghiên cứu nồng độ Procalcitonin huyết thanh ở bệnh nhân nam đợt cấp bệnh phổi tắc nghẽn mạn tính có hút thuốc lá. Tạp chí Y Dược học Cần Thơ. 2019;7.
12. Zhang Y, Zhou L. Diagnostic value of C-reactive protein and procalcitonin for bacterial infection in acute exacerbations of chronic obstructive pulmonary disease. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2014;39(9):939-943. doi: 10.11817/j.issn.1672-7347.2014.09.013.