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Published: 2023-01-30
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DOI: https://doi.org/10.52852/tcncyh.v160i12V2.1258
Issue
Vol. 160 No. 12V2 (2022)
Section
Các bài báo
How to Cite
Trang, M. T. ., Tiệp, N. K. ., & Nhung, P. H. . (2023). 2. The minimum inhibitory concentration of vancomycin and the antibiotic persistence character to vancomycin of Staphylococcus aureus. Journal of Medical Research, 160(12V2), 12-18. https://doi.org/10.52852/tcncyh.v160i12V2.1258

2. The minimum inhibitory concentration of vancomycin and the antibiotic persistence character to vancomycin of Staphylococcus aureus

Mai Thi Trang, Nguyen Khac Tiep, Pham Hong Nhung

Main Article Content

Abstract

This study assessed the minimum inhibitory concentration (MIC) of vancomycin in inhibiting the growth of Staphylococcus aureus (S. aureus) and its antibiotic persistence character. A total of 213 Staphylococcus aureus strains were isolated from blood or catheter specimen by the Microbiology Department of Bach Mai Hospital from 02/2022 to 08/ 2022. Vancomycin’s MIC was determined using the broth microdilution method. The result shows that the frequency of MRSA was 61.4%. Vancomycin’s MIC ranged from 0.25 µg/ml to 1 µg/ml, and 128 strains (60.1%) had MIC of vancomycin of 1 µg/ml. There was no case of resistance to vancomycin. After performing antibiotic persistence test of 52 randomly-chosen strains, high persister frequency was observed in all of them. There was no significant differences in persistence frequency when comparing S. aureus strains with MIC of 0.5 µg/ml and strains with MIC of 1 µg/ml.

Article Details

Keywords

Staphylococcus aureus, MIC, persistence antibiotic, vancomycin

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