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Published: 2022-11-29
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DOI: https://doi.org/10.52852/tcncyh.v159i11.1289
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Vol. 159 No. 11 (2022)
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Huy, T. L. ., & Anh, T. Đình . (2022). 22. Treatment result of first-line afatinib for advanced egfr-mutant non-small cell lung cancer in Hanoi Medical University Hospital. Journal of Medical Research, 159(11), 178-186. https://doi.org/10.52852/tcncyh.v159i11.1289

22. Treatment result of first-line afatinib for advanced egfr-mutant non-small cell lung cancer in Hanoi Medical University Hospital

Trinh Le Huy, Tran Dinh Anh

Main Article Content

Abstract

This is a retrospective descriptive study with longitudinal follow-up aimed to assess the efficacy of first-line afatinib treatment in patients with stage IIIC, IV NSCLC with EGFR mutations. The patients were treated at the Department of Oncology and Palliative care, Hanoi Medical University Hospital from January 2018 to June 2021. In 34 patients enrolled in the study, the rate of Del19 and L585R mutations was 44.1% and 20.6%, respectively. The remaining cases were rare mutations or compound mutations. At the time of 8 - 12 weeks, the overall response rate to afatinib reached 76.5%, the stable disease status accounted for 20.6%, and only 2.9% of the cases progressed. The median progression-free survival (PFS) was 12.0 months (5.9 - 18.0 months). There was no statistically significant difference in progression-free survival in exploratory analysis of factors associated with survival. The most common side effects were skin rash (35.3%), paronychia (35.3%), and diarrhea (32.4%). No patient reported grade 4 toxicity or discontinued treatment due to afatinib's toxicity.

Article Details

Keywords

Advanced Non-small cell lung cancer (NSCLC), EGFR mutation, afatinib

References

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