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Published: 2023-04-27
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DOI: https://doi.org/10.52852/tcncyh.v165i4.1551
Issue
Vol. 165 No. 4 (2023)
Section
Các bài báo
How to Cite
Duyên, N. T., Viện, M. V., Phương, N. T. M., Nga, L. T. T., & Bình, N. T. (2023). 21. Adverse events after autologous hematopoietic stem cell transplantation in autoimmune patients. Journal of Medical Research, 165(4), 170-178. https://doi.org/10.52852/tcncyh.v165i4.1551

21. Adverse events after autologous hematopoietic stem cell transplantation in autoimmune patients

Nguyen Thi Duyen, Mai Van Vien, Nguyen Thi Minh Phuong, Le Thi Thu Nga, Nguyen Thanh Binh

Main Article Content

Abstract

A prospective, cross-sectional descriptive study on 8 autoimmune patients receiving autologous hematopoietic stem cell transplantation at 108 Military Central Hospital with the aim of evaluating adverse events after transplantation. Adverse events were determined according to the CTCAE 5.0 guidelines 2017. The results showed that during the stem cell mobilization and harvesting phase, the adverse events were fatigue (100%), anorexia (87.5%), nausea (75%), vomiting (25%), abdominal pain (12.5%), bone pain (87.5%), decreased hemoglobin (50%), leukopenia, neutropenia and platelets were 62.5%, ALT increased (12.5%). Adverse events were mild and transient, grade 1 to 2 according to CTCAE 5.0. In the conditioning treatment phase, there were adverse events including fatigue (100%), anorexia (100%), nausea (87.5%), vomiting (87.5%), oral mucositis (25%), diarrhea (62.5%), abdominal pain (37.5%), bone pain (75%), febrile neutropenia (87.5%); cytopenia was found in 100% of patients. Liver function (AST and ALT) slightly increased at grade 1 and 2 (accounting for 75%), not required treatment. Renal function is not affected. One patient (12.5%) had sepsis caused by Klebsiella pneumoniae in the period of cytopenia, and CMV, BK virus reactivation, all responded to treatment. There were no deaths related to stem cell transplantation.

Article Details

Keywords

Hematopoietic stem cell transplantation, autoimmune disease, CTCAE, systemic lupus erythematosus, myasthenia gravis, adverse events

References

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