36. Tác dụng bảo vệ gan, phục hồi tổn thương gan và chống oxy hoá của viên nang cứng Silymax Complex trên thực nghiệm

Abstract

The purpose of this study was to evaluate the hepatoprotective activity, liver function recovery, and antioxidant activity of Silymax Complex hard capsules . At both models (protection and recovery of liver function), mice were divided randomly into 5 groups of ten mice per cage: control, model, positive control (silymarine), Silymax Complex at 0.53 g/kg/day and Silymax Complex at 1.59 g/kg/day. Of the hepatoprotective model, mice were orally administered researched products and distilled water for 8 consecutive days. On the 8th day, after 2 hours of administration, mice of group 2 to 5 were given paracetamol 400 mg/kg orally in order to induce liver cell damage. Of the model of liver function recovery, mice of group 2 to 5 was given a single dose of paracetamol 400 mg/kg. 2 hours later, mice were administered sterile or research products for 5 consecutive days. All indexes including AST, ALT, GGT levels, albumin, total bilirubin concentration, liver MDA (malondialdehyd) concentration, and microscopic analyses of livers were evaluated. Results showed Silymax Complex at both doses exhibited hepatoprotective effect and liver damage recovery on paracetamol-induced liver injury.