38. Evaluating the effects of a nasal spray of NaCl 2.7% and hyaluronic acid combination on an experimental model of rhinitis
Main Article Content
Abstract
This study evaluated the anti-inflammatory effect of a nasal spray containing NaCl 2.7% with hyaluronic acid in a rat model of ammoniac 15%-induced rhinitis. For three days, the rhinitis rats were sprayed with the test solution at a dose of 200µl once a day, or 200µl twice a day, or 200µl fluticasone propionate 50 µg/0,05ml once a day. The rats underwent nasal and pharyngeal endoscopies to evaluate the inflammatory degrees at pre-treatment, immediately after ammoniac administration, and every day for 3 days following each administration of the nasal spray. The results showed that the test solution displayed an anti-inflammatory effect by significantly decreasing the inflammatory levels estimated by the nasal and pharyngeal endoscopic images, compared to the control group. Therefore, the nasal spray containing NaCl 2.7% in hyaluronic acid had an anti-inflammatory effect on the rat model of ammoniac 15%-induced rhintis and pharyngitis.
Article Details
Keywords
Nasal spray containing NaCl 2.7% with acid hyaluronic, rhinitis, ammoniac, expeimental
References
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