21. Đánh giá giá trị sử dụng một số công thức tính toán nồng độ low density lipoprotein cholesterol máu

Abstract

Cholesterol in low-density lipoprotein (LDL-C) screening test is important for monitoring risk and treatment effectiveness of cardiovascular diseases. LDL-C can be measured directly or calculated using a formula. This study evaluated the value of Friedewald (F), Hatta (H), Puavilai (P), Martin (M), and Sampson (S) formulas by comparing the results of direct LDL-C quantification and calculated LDL-C using D and D% calculation, Pearson correlation analysis; we evaluated the value of the formula according to NCEP - ATP III classification in two groups Triglyceride < 4.50 mmol/L (Triglyceride < 400 mg/dL) and 4.50 - 8.45 mmol/L (400 - 750 mg/dL), and the correlation with Triglyceride and HDL-C levels. Results: In samples with Triglyceride < 4.50 mmol/L, LDL-C calculated by Martin, Sampson, Puavilai is the most consistent with direct LDL-C, better than Friedewald fomula and Hatta formula. In samples with Triglyceride 4.50 - 8.45 mmol/L, LDL-C calculated by Sampson, Puavilai, Martin is the most consistent with direct LDL-C. We suggest that the three formulas Puavilai, Sampson, Martin are suitable for calculating LDL-C results of patients in both Triglyceride concentration ranges of Triglyceride < 4.50 mmol/L and 4.50 - 8.45 mmol/L.