21. Độc tính cấp và bán trường diễn của viên nang cứng từ bài thuốc “Dạ dày HĐ” trên thực nghiệm

Abstract

This study aimed to evaluate the acute and sub-chronic toxicity of capsule extracted from Da Day HD herbal formular in the experimental animals. The acute toxicity was performed based on the Litchfield - Wilcoxon method. The sub-chronic toxicity was evaluated according to the World Health Organization's guidance. The results showed that the highest dose of capsule extracted from Da Day HD herbal formular (45.0 g/kg b.w./day, 51 times as high as the maximal recommended human dose) did not show acute oral toxicity in mice and the median lethal dose (LD50) was not determined. Administration of capsule extracted from Da Day HD herbal formular at 0.48 g/kg b.w./day (equivalent to clinical dose) and 1.44 g/kg body weight (three times as high as the clinical dose) in 12 consecutive weeks did not produce any significant detrimental effect on the body weight, hematological and biochemical parameters, as well as the gross and microscopic images of the rats’ liver and kidney, compared to control group (p > 0.05).