23. Hepatoprotective effect of Gydenphy capsule on mice with acute liver injury model induced by paracetamol
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Abstract
The purpose of this study was to evaluate the hepatoprotective effect of Gydenphy capsule including Phyllanthus emblica, Gynostemma pentaphyllum, Dendrobium officinale against paracetamol-induced acute hepatotoxicity in a mouse model. Mice were orally administered distilled water or silymarine at 70 mg/kg/day or Gydenphy capsule at 576 mg/kg/day and 1152 g/kg/day for 8 consecutive days. On the 8th day, after one hour of administration, mice were given paracetamol 400 mg/kg orally to induce liver cell damage. All indexes including AST, ALT, liver MDA (malondialdehyd) concentration, liver GSH (glutathione) level and microscopic analyses of livers were evaluated. Results showed Gydenphy capsule at 576 mg/kg/day and 1152 g/kg/day exhibited hepatoprotective effect on paracetamol-induced acute liver injury.
Article Details
Keywords
Gydenphy capsule, paracetamol, hepatoprotective effect, Swiss mice
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