14. Results of “Ban xia xie xin” in treating of gastroesophageal reflux disease
Main Article Content
Abstract
This research was conducted to evaluate the results of the Ban xia xie xin decoction in the treatment of gastroesophageal reflux disease. This study was designed as a controlled interventional clinical trial, comparing before and after treatment. Sixty patients diagnosed with gastroesophageal reflux disease were divided into 2 groups, according to the method of homogenous pairing of age, gender, and degree of GerdQ. The study group used the Ban xia xie xin decoction at a dose of 1 remedy/day, the control group used Omeprazol at a dose of 40 mg/day, followed up for 28 days. The results showed that in both groups, the mean score of symptoms of gastroesophageal reflux disease, the mean score of GerdQ decreased statistically significantly after treatment (p < 0.05) and the study group improved better than the control group. No side effect of the remedy on clinical and subclinical has been found.
Article Details
Keywords
Gastroesophageal reflux disease (GERD), Ban xia xie xin Decoction
References
1. Acid Reflux (GER & GERD) in Adults - NIDDK. National Institute of Diabetes and Digestive and Kidney Diseases. Accessed January 20, 2024. https://www.niddk.nih.gov/health-information/digestive-diseases/acid-reflux-ger-gerd-adults
2. Boulton KHA, Dettmar PW. A narrative review of the prevalence of gastroesophageal reflux disease (GERD). Annals of Esophagus. 2022;5(0). doi:10.21037/aoe-20-80
3. Belhocine K, Galmiche JP. Epidemiology of the Complications of Gastroesophageal Reflux Disease. Digestive Diseases. 2009;27(1):7-13. doi:10.1159/000210097
4. Katz PO, Dunbar KB, Schnoll-Sussman FH, Greer KB, Yadlapati R, Spechler SJ. ACG Clinical Guideline for the Diagnosis and Management of Gastroesophageal Reflux Disease. The American Journal of Gastroenterology. 2022;117(1):27-56. doi:10.14309/ajg.0000000000001538
5. Gyawali CP, Fass R. Management of Gastroesophageal Reflux Disease. Gastroenterology. 2018;154(2):302-318. doi:10.1053/j.gastro.2017.07.049
6. Yibirin M, De Oliveira D, Valera R, Plitt AE, Lutgen S. Adverse Effects Associated with Proton Pump Inhibitor Use. Cureus. 13(1):e12759. doi:10.7759/cureus.12759
7. Nguyễn Thiên Quyến, Đào Trọng Cường. Chẩn đoán phân biệt chứng trạng trong Đông y. Nhà xuất bản văn hoá dân tộc; 2010.
8. 熊曼琪. 伤寒学. 中国中医药出版社; 2007.123
Hùng Man Kỳ. Thương Hàn Luận. Nhà xuất bản Trung y dược Trung Quốc; 2007:123
9. Attilio, Alberto. Disorders of the Spleen and Stomach. The Lantern. Published online January 1, 2005. Accessed January 25, 2024. https://www.academia.edu/51309131/Disorders_of_the_Spleen_and_Stomach
10. Jang M woong, Lim S woo. Experimental Study for Effect of Banhasasim-tang on Mice with Reflux Esophagitis. The Journal of Internal Korean Medicine. 2013;34(4):362-374.
11. Hunt R, Armstrong D, Katelaris P, et al. World Gastroenterology Organisation Global Guidelines: GERD Global Perspective on Gastroesophageal Reflux Disease. J Clin Gastroenterol. 2017;51(6):467-478. doi:10.1097/MCG.0000000000000854
12. Suzuki H, Matsuzaki J, Okada S, Hirata K, Fukuhara S, Hibi T. Validation of the GerdQ questionnaire for the management of gastro-oesophageal reflux disease in Japan. United European Gastroenterol J. 2013;1(3):175-183. doi:10.1177/2050640613485238
13. Nguyễn Nhược Kim, Nguyễn Thị Thu Hà. Bệnh học nội khoa Y học cổ truyền. Nhà xuất bảnY học; 2016.
14. Jones R, Junghard O, Dent J, et al. Development of the GerdQ, a tool for the diagnosis and management of gastro-oesophageal reflux disease in primary care. Aliment Pharmacol Ther. 2009;30(10):1030-1038. doi:10.1111/j.1365-2036.2009.04142.x
15. Antunes C, Aleem A, Curtis SA. Gastroesophageal Reflux Disease. In: StatPearls. StatPearls Publishing; 2023. Accessed January 11, 2024. http://www.ncbi.nlm.nih.gov/books/NBK441938/
16. Nguyễn Nhược Kim. Lý luận Y học cổ truyền. Nhà xuất bản giáo dục Việt Nam; 2017.
17. Chen H yu, Li Q, Zhou P ping, et al. Mechanisms of Chinese Medicine in Gastroesophageal Reflux Disease Treatment: Data Mining and Systematic Pharmacology Study. Chin J Integr Med. 2023;29(9):838-846. doi:10.1007/s11655-022-3538-3
18. Sharma V, Katiyar A, Agrawal RC. Glycyrrhiza glabra: Chemistry and Pharmacological Activity. Sweeteners. Published online July 31, 2017:87-100. doi:10.1007/978-3-319-27027-2_21
19. Jeon YJ, Lee JS, Cho YR, et al. Banha-sasim-tang improves gastrointestinal function in loperamide-induced functional dyspepsia mouse model. Journal of Ethnopharmacology. 2019;238:111834. doi:10.1016/j.jep.2019.111834
20. Kim SK, Joung JY, Ahn YC, Jung IC, Son CG. Beneficial Potential of Banha-Sasim-Tang for Stress-Sensitive Functional Dyspepsia via Modulation of Ghrelin: A Randomized Controlled Trial. Frontiers in Pharmacology. 2021;12. Accessed January 22, 2024. https://www.frontiersin.org/articles/10.3389/fphar.2021.636752
21. Jang M woong, Lim S woo. Experimental Study for Effect of Banhasasim-tang on Mice with Reflux Esophagitis. The Journal of Internal Korean Medicine. 2013;34(4):362-374.
22. Lee S hee, Baik TH, Lee S hee, Baik TH. A Comparative Study on the Effects of Pinellia ternata, Zingiber officinale and Sobanhatang on Reflux Esophagitis. J Korean Med. 2019;40(2):17-34. doi:10.13048/jkm.19014
23. Lee JS, Kim JS, Ryu BH, Yoon SH. Effect of Banhasasimtang Granule on Gastric Emptying in Rats. The Journal of Internal Korean Medicine. 2006;27(2):471-479.
24. Ling Y, Yang D, Shao W. Understanding vomiting from the perspective of traditional Chinese medicine. Ann Palliat Med. 2012;1(2):143-160. doi:10.3978/j.issn.2224-5820.2012.07.03
25. Walstab J, Krüger D, Stark T, et al. Ginger and its pungent constituents non-competitively inhibit activation of human recombinant and native 5-HT3 receptors of enteric neurons. Neurogastroenterol Motil. 2013;25(5):439-447, e302. doi:10.1111/nmo.12107
26. Dai Y, Zhang Y, Li D, Ye J, Chen W, Hu L. Efficacy and Safety of Modified Banxia Xiexin Decoction (Pinellia Decoction for Draining the Heart) for Gastroesophageal Reflux Disease in Adults: A Systematic Review and Meta-Analysis. Evid Based Complement Alternat Med. 2017;2017:9591319. doi:10.1155/2017/9591319
2. Boulton KHA, Dettmar PW. A narrative review of the prevalence of gastroesophageal reflux disease (GERD). Annals of Esophagus. 2022;5(0). doi:10.21037/aoe-20-80
3. Belhocine K, Galmiche JP. Epidemiology of the Complications of Gastroesophageal Reflux Disease. Digestive Diseases. 2009;27(1):7-13. doi:10.1159/000210097
4. Katz PO, Dunbar KB, Schnoll-Sussman FH, Greer KB, Yadlapati R, Spechler SJ. ACG Clinical Guideline for the Diagnosis and Management of Gastroesophageal Reflux Disease. The American Journal of Gastroenterology. 2022;117(1):27-56. doi:10.14309/ajg.0000000000001538
5. Gyawali CP, Fass R. Management of Gastroesophageal Reflux Disease. Gastroenterology. 2018;154(2):302-318. doi:10.1053/j.gastro.2017.07.049
6. Yibirin M, De Oliveira D, Valera R, Plitt AE, Lutgen S. Adverse Effects Associated with Proton Pump Inhibitor Use. Cureus. 13(1):e12759. doi:10.7759/cureus.12759
7. Nguyễn Thiên Quyến, Đào Trọng Cường. Chẩn đoán phân biệt chứng trạng trong Đông y. Nhà xuất bản văn hoá dân tộc; 2010.
8. 熊曼琪. 伤寒学. 中国中医药出版社; 2007.123
Hùng Man Kỳ. Thương Hàn Luận. Nhà xuất bản Trung y dược Trung Quốc; 2007:123
9. Attilio, Alberto. Disorders of the Spleen and Stomach. The Lantern. Published online January 1, 2005. Accessed January 25, 2024. https://www.academia.edu/51309131/Disorders_of_the_Spleen_and_Stomach
10. Jang M woong, Lim S woo. Experimental Study for Effect of Banhasasim-tang on Mice with Reflux Esophagitis. The Journal of Internal Korean Medicine. 2013;34(4):362-374.
11. Hunt R, Armstrong D, Katelaris P, et al. World Gastroenterology Organisation Global Guidelines: GERD Global Perspective on Gastroesophageal Reflux Disease. J Clin Gastroenterol. 2017;51(6):467-478. doi:10.1097/MCG.0000000000000854
12. Suzuki H, Matsuzaki J, Okada S, Hirata K, Fukuhara S, Hibi T. Validation of the GerdQ questionnaire for the management of gastro-oesophageal reflux disease in Japan. United European Gastroenterol J. 2013;1(3):175-183. doi:10.1177/2050640613485238
13. Nguyễn Nhược Kim, Nguyễn Thị Thu Hà. Bệnh học nội khoa Y học cổ truyền. Nhà xuất bảnY học; 2016.
14. Jones R, Junghard O, Dent J, et al. Development of the GerdQ, a tool for the diagnosis and management of gastro-oesophageal reflux disease in primary care. Aliment Pharmacol Ther. 2009;30(10):1030-1038. doi:10.1111/j.1365-2036.2009.04142.x
15. Antunes C, Aleem A, Curtis SA. Gastroesophageal Reflux Disease. In: StatPearls. StatPearls Publishing; 2023. Accessed January 11, 2024. http://www.ncbi.nlm.nih.gov/books/NBK441938/
16. Nguyễn Nhược Kim. Lý luận Y học cổ truyền. Nhà xuất bản giáo dục Việt Nam; 2017.
17. Chen H yu, Li Q, Zhou P ping, et al. Mechanisms of Chinese Medicine in Gastroesophageal Reflux Disease Treatment: Data Mining and Systematic Pharmacology Study. Chin J Integr Med. 2023;29(9):838-846. doi:10.1007/s11655-022-3538-3
18. Sharma V, Katiyar A, Agrawal RC. Glycyrrhiza glabra: Chemistry and Pharmacological Activity. Sweeteners. Published online July 31, 2017:87-100. doi:10.1007/978-3-319-27027-2_21
19. Jeon YJ, Lee JS, Cho YR, et al. Banha-sasim-tang improves gastrointestinal function in loperamide-induced functional dyspepsia mouse model. Journal of Ethnopharmacology. 2019;238:111834. doi:10.1016/j.jep.2019.111834
20. Kim SK, Joung JY, Ahn YC, Jung IC, Son CG. Beneficial Potential of Banha-Sasim-Tang for Stress-Sensitive Functional Dyspepsia via Modulation of Ghrelin: A Randomized Controlled Trial. Frontiers in Pharmacology. 2021;12. Accessed January 22, 2024. https://www.frontiersin.org/articles/10.3389/fphar.2021.636752
21. Jang M woong, Lim S woo. Experimental Study for Effect of Banhasasim-tang on Mice with Reflux Esophagitis. The Journal of Internal Korean Medicine. 2013;34(4):362-374.
22. Lee S hee, Baik TH, Lee S hee, Baik TH. A Comparative Study on the Effects of Pinellia ternata, Zingiber officinale and Sobanhatang on Reflux Esophagitis. J Korean Med. 2019;40(2):17-34. doi:10.13048/jkm.19014
23. Lee JS, Kim JS, Ryu BH, Yoon SH. Effect of Banhasasimtang Granule on Gastric Emptying in Rats. The Journal of Internal Korean Medicine. 2006;27(2):471-479.
24. Ling Y, Yang D, Shao W. Understanding vomiting from the perspective of traditional Chinese medicine. Ann Palliat Med. 2012;1(2):143-160. doi:10.3978/j.issn.2224-5820.2012.07.03
25. Walstab J, Krüger D, Stark T, et al. Ginger and its pungent constituents non-competitively inhibit activation of human recombinant and native 5-HT3 receptors of enteric neurons. Neurogastroenterol Motil. 2013;25(5):439-447, e302. doi:10.1111/nmo.12107
26. Dai Y, Zhang Y, Li D, Ye J, Chen W, Hu L. Efficacy and Safety of Modified Banxia Xiexin Decoction (Pinellia Decoction for Draining the Heart) for Gastroesophageal Reflux Disease in Adults: A Systematic Review and Meta-Analysis. Evid Based Complement Alternat Med. 2017;2017:9591319. doi:10.1155/2017/9591319