18. A study on the hypoglycemic action of guava leaf extract in type 2 diabetes mice
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Abstract
The purpose of this study was to investigate the hypoglycemic action of guava leaf extract on the mouse model with type 2 diabetes caused by a high-fat diet plus streptozotocin. This research was conducted of two stages: In the first stage, diabetes mellitus type 2 condition was induced in Swiss mice by a high-fat diet and streptozotocin for eight weeks; in the second stage, guava leaf extract was administered orally to mice at low (100 mg/kg) and high (300 mg/kg) doses for 2 weeks. The obtained data show that guava leaf extract at both studied doses reduced blood glucose concentrations, with a tendency to reduce TC, TG, and LDL-C concentrations simultaneously with increasing HDL-C, accompanied by an improvement in the degree of liver and pancreas damage on microscopic examination. Guava leaf extract at the 300 mg/kg exhibited a more potent hypoglycemic effect than 100 mg/kg. The above results suggest guava left extract has a blood glucose-lowering effect which was dose-dependent.
Article Details
Keywords
guava leaf, diabetes, streptozocin, mice
References
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